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1.发明公开DERIVATIVES OF gp160 AND VACCINES BASED ON gp160 OR A DERIVATIVE THEREOF, CONTAINING AN ADJUVANT 失效佐剂含衍生物GP160，疫苗ON或gp160的DERIVATBASIN。
公开(公告)号：EP0550485A1
公开(公告)日：1993-07-14
申请号：EP91916067.0
申请日：1991-09-21
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
摘要： Nouvelles formes de gp160, sensiblement non clivables, et formulations de vaccins contenant de la gp160 ou un de ses dérivés, comportant un adjuvant 3D-Mpl. Les compositions s'utilisent pour le traitement immunotherapeutique et immunoprophylactique des infections VIH.
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公开(公告)号：EP0649470A1
公开(公告)日：1995-04-26
申请号：EP93912991.0
申请日：1993-06-15
CPC分类号： A61K39/39 , A61K39/015 , A61K39/12 , A61K39/245 , A61K2039/5256 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C12N2710/16634 , C12N2710/24143
摘要： Immediate early HSV-2 viral protein ICP27 recognised by cytolytic T-lymphocyte (CTL) cells in humans, methods for preparation thereof and use in vaccine.
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3.发明授权HERPES SIMPLEX VACCINE COMPRISING HSV GLYCOPROTEIN GD AND 3 DEACYLATED MONOPHOSPHORYL LIPID A 失效单纯疱疹疫苗的HSV糖蛋白gD和3-脱酰基单磷酰脂质A包含
公开(公告)号：EP0576478B2
公开(公告)日：2001-04-18
申请号：EP92906441.8
申请日：1992-03-17
发明人： FRANCOTTE, Myriam , PRIEELS, Jean-Paul , SLAOUI, Moncef , GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude
IPC分类号： A61K39/245
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/541 , A61K2039/545 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , C12N2710/16634
摘要： Novel herpes simplex (HSV) vaccine formulations are provided. These comprise HSV glycoprotein gD or immunological fragments in conjunction with 3 Deacylated monophosphoryl lipid A.
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4.发明公开HERPES SIMPLEX VACCINE COMPRISING HSV GLYCOPROTEIN GD AND 3 DEACYLATED MONOPHOSPHORYL LIPID A 失效单纯疱疹疫苗，THE HSV糖蛋白gD和3-脱酰基单磷酰脂质A含有。
公开(公告)号：EP0576478A1
公开(公告)日：1994-01-05
申请号：EP92906441.0
申请日：1992-03-17
发明人： FRANCOTTE, Myriam , PRIEELS, Jean-Paul , SLAOUI, Moncef , GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/541 , A61K2039/545 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , C12N2710/16634
摘要： On décrit de nouvelles formulations de vaccin contre le virus de l'herpès simplex (HSV) comprenant la glycoprotéine gD du HSV ou des fragments immunologiques conjugués avec le lipide A de monophosphoryle 3-déacylé.
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公开(公告)号：EP0671948B1
公开(公告)日：1997-08-13
申请号：EP93912990.4
申请日：1993-06-15
发明人： PRIEELS, Jean-Paul , GARCON-JOHNSON, Nathalie Marie-Josephe Claude , SLAOUI, Moncef , PALA, Pietro
CPC分类号： A61K39/292 , A61K39/015 , A61K39/12 , A61K39/245 , A61K39/29 , A61K39/39 , A61K2039/55505 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C12N2710/16634 , C12N2730/10134 , Y02A50/412 , Y02A50/464
摘要： The present invention provides vaccine compositions comprising 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of CTL and gamma IFN responses.
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6.发明授权HERPES SIMPLEX VACCINE COMPRISING HSV GLYCOPROTEIN GD AND 3 DEACYLATED MONOPHOSPHORYL LIPID A 失效单纯疱疹疫苗，THE HSV糖蛋白gD和3-脱酰基单磷酰脂质A含有。
公开(公告)号：EP0576478B1
公开(公告)日：1995-10-18
申请号：EP92906441.8
申请日：1992-03-17
发明人： FRANCOTTE, Myriam , PRIEELS, Jean-Paul , SLAOUI, Moncef , GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude
IPC分类号： A61K39/245
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/541 , A61K2039/545 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , C12N2710/16634
摘要： Novel herpes simplex (HSV) vaccine formulations are provided. These comprise HSV glycoprotein gD or immunological fragments in conjunction with 3 Deacylated monophosphoryl lipid A.
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公开(公告)号：EP0671948A1
公开(公告)日：1995-09-20
申请号：EP93912990.0
申请日：1993-06-15
发明人： PRIEELS, Jean-Paul , GARCON-JOHNSON, Nathalie Marie-Josephe Claude , SLAOUI, Moncef , PALA, Pietro
CPC分类号： A61K39/292 , A61K39/015 , A61K39/12 , A61K39/245 , A61K39/29 , A61K39/39 , A61K2039/55505 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C12N2710/16634 , C12N2730/10134 , Y02A50/412 , Y02A50/464
摘要： The present invention provides vaccine compositions comprising 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of CTL and gamma IFN responses.
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