公开(公告)号：EP0866126A1

公开(公告)日：1998-09-23

申请号：EP98301122.2

申请日：1998-02-16

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： Bergsma, Derk J. ,  Sathe, Ganesh M. ,  Fuetterer, Wendy S. ,  Mao, Joyce Y.

IPC分类号： C12N15/12 ,  C07K14/705 ,  A61K38/17 ,  G01N33/74 ,  C12Q1/68 ,  C07K16/28 ,  C12N15/11 ,  A61K48/00

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： HNFDY20 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNFDY20 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

摘要翻译： HNFDY20多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HNFDY20多肽和多核苷酸的方法; 疼痛; 癌症; 厌食; 贪食症; 哮喘; 帕金森病; 急性心力衰竭 低血压; 高血压; 尿潴留 骨质疏松症; 心绞痛; 心肌梗死; 溃疡; 哮喘; 过敏; 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征等。