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    SILK NANOFIBER NERVE CONDUIT AND METHOD FOR PRODUCING THEREOF
    1.
    发明公开
    SILK NANOFIBER NERVE CONDUIT AND METHOD FOR PRODUCING THEREOF 有权
    VERFAHREN ZUR HERSTELLUNG EINER SEIDENNANOFASER-NERVENLEITUNG

    公开(公告)号：EP2465472A2

    公开(公告)日：2012-06-20

    申请号：EP10808360.1

    申请日：2010-08-11

    申请人： SNU R&DB Foundation

    发明人： PARK, Young Hwan ,  KI, Chang Seok ,  KIM, Hyun Jeung ,  PARK, Sook Young

    IPC分类号： A61F2/02

    CPC分类号： A61F2/04 ,  A61L27/3604 ,  A61L27/56 ,  A61L2400/12 ,  A61L2430/32 ,  D01D1/02 ,  D01D1/06 ,  D01D5/003 ,  D01D5/0046 ,  D01D5/0076 ,  D01F4/02

    摘要： The present invention relates to a silk nanofiber nerve conduit characterized in that fibroin nanofibers having a diameter of 200 to 400 nm, originated from silk fiber, are stacked layer upon layer to form a porous conduit-shape; and a method for producing thereof, more specifically, to a method for producing a silk nanofiber nerve conduit comprising: (Step 1) preparing a fibrous spinning solution; (Step 2) producing a silk nanofiber of conduit-shape by electrospinning the fibrous spinning solution prepared in step 1 into the cylindrical collecting part coated with polyethyleneoxide; and (Step 3) separating a silk nanofiber of conduit-shape produced in step 2 from the collecting part. The silk nanofiber nerve conduit of the present invention has excellent biocompatibility; allows the body fluid to be exchanged inter in and out of conduit through pores of the conduit, as well; has a proper elasticity, tensile strength, and tear strength. Due to these properties, the silk nanofiber nerve conduit of the present invention helps the regeneration of the nerve injury to recover a motor skill and a sensory function, and thus shows an excellent effect of nerve regeneration. Therefore, the silk nanofiber nerve conduit of the present invention can be used in treating a nerve injury instead of an existing synthetic polymeric nerve conduit.

    摘要翻译： 本发明涉及一种丝绸纳米纤维神经管，其特征在于，由丝纤维构成的直径为200〜400nm的丝心蛋白纳米纤维层叠层叠形成多孔导管状， 及其制造方法，更具体地说，涉及一种丝素纳米纤维神经导管的制造方法，包括：（工序1）制备纤维纺丝溶液; （步骤2）通过将步骤1中制备的纤维纺丝溶液静电纺丝到涂覆有聚环氧乙烷的圆柱形收集部分中来生产导管形状的丝素纳米纤维; 和（步骤3）将在步骤2中产生的导管形状的丝纳米纤维与收集部分分离。 本发明的丝素纳米纤维神经管具有优异的生物相容性; 允许体液通过导管的孔隙进入和导出管道; 具有适当的弹性，拉伸强度和撕裂强度。 由于这些特性，本发明的丝纳米纤维神经管有助于神经损伤的再生以恢复运动技能和感觉功能，因此显示出神经再生的优异效果。 因此，本发明的丝纳米纤维神经管可用于治疗神经损伤而不是现有的合成聚合物神经管。