MODIFIED FIBROIN
    4.
    发明公开
    MODIFIED FIBROIN 审中-公开

    公开(公告)号:EP3660036A1

    公开(公告)日:2020-06-03

    申请号:EP18838960.5

    申请日:2018-07-25

    申请人: Spiber Inc. Riken

    摘要: The present invention relates to a modified fibroin including a domain sequence represented by Formula 1: [(A) n motif-REP] m or Formula 2: [(A) n motif-REP] m -(A) n motif, in which the domain sequence has an amino acid sequence with a reduced content of a glutamine residue equivalent to an amino acid in which one or a plurality of glutamine residues in REP are deleted or substituted with other amino acid residues, as compared with a naturally occurring fibroin. [In Formula 1 and Formula 2, (A) n motif represents an amino acid sequence consisting of 4 to 27 amino acid residues, and the number of alanine residues with respect to the total number of amino acid residues in the (A) n motif is 80% or more. REP represents an amino acid sequence consisting of 10 to 200 amino acid residues, m represents an integer of 10 to 300. A plurality of (A) n motifs may be the same amino acid sequence or different amino acid sequences.]