Use of histamine derivatives for the preparation of drugs, new histamine derivatives and drugs
    2.
    发明公开
    Use of histamine derivatives for the preparation of drugs, new histamine derivatives and drugs 失效
    用于生产药物,新型组胺衍生物和药物使用组胺衍生物。

    公开(公告)号:EP0531219A1

    公开(公告)日:1993-03-10

    申请号:EP92402418.5

    申请日:1992-09-04

    IPC分类号: A61K31/415 C07D233/64

    CPC分类号: C07D233/64

    摘要: The use for the preparation of drugs having H₃ histamine receptor agonist properties on the central nervous system of the 4-(4(5)-imidazolyl) butyramidine (compound A), the O-[2-(4(5)-imidazolyl)-ethyl] isourea (compound C) the S-[2-(4(5)-imidazolyl) ethyl] isothiourea (compound E)as well as their N-methyl derivatives (compound B, D, F), and new compounds B, C, D, being useful for the preparation of drugs to be used as anti-migraine hypnotic, sleep-inducer, tranquillizer, sedative, anxiolytic, anti-asthmatic and anti-inflammatory agents, notably for the bronchi, the skin or the eyes, or as anti-gastric ulcer agents, and drugs comprising these compounds.

    摘要翻译: 为的4-(4-(5)咪唑基)丁脒(化合物A)的中枢神经系统具有H3组胺受体激动剂性质的药物制备中的用途,所述O- [2-(4(5)咪唑基) 乙基]异脲(化合物C)的S- [2-(4(5) - 咪唑基)乙基]异硫脲(化合物e),以及它们的N-甲基衍生物(化合物B,D,F),和新的化合物乙 ,C,D,用于药物的制备是有用的,用作抗偏头痛催眠,睡眠诱导剂,镇静剂,镇静,抗焦虑,抗哮喘和抗炎剂,特别是用于支气管,皮肤或眼睛 ,或作为抗胃溃疡药物,和药物,其包括合成的化合物。