公开(公告)号：EP1097150B1

公开(公告)日：2004-03-24

申请号：EP99931792.8

申请日：1999-06-11

申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng, Xin ,  SHEN, Yeelana

IPC分类号： C07D403/06 ,  C07D403/14 ,  C07D417/14 ,  A61K31/415 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/14

摘要： The present invention is directed to imidazolyl derivatives of formula (II), wherein the variables are defined in the specification, which are useful as prenyl transferase inhibitors.

公开(公告)号：EP1919492A2

公开(公告)日：2008-05-14

申请号：EP06800353.2

申请日：2006-07-24

申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng Xin ,  EYNON, John, S. ,  SHEN, Yeelana

IPC分类号： A61K38/00

CPC分类号： C07K14/72 ,  C07K5/06026 ,  C07K5/06086

摘要： A family of peptides and peptidomimetic compounds useful as GHS analogs according to either formula (I) or (II) as depicted below: or a pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification.

公开(公告)号：EP1928489A2

公开(公告)日：2008-06-11

申请号：EP06825217.0

申请日：2006-09-27

申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng, Xin ,  CULLER, Michael, DeWitt ,  SHEN, Yeelana ,  COMSTOCK, Jeanne, Mary

IPC分类号： A61K38/22

CPC分类号： C07K14/60 ,  A61K38/00 ,  G01N2500/00 ,  Y02A50/463 ,  Y02A50/475

摘要： The invention comprises peptidyl analogs according to formulae (I) or (II) as depicted below: (R2R3)-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13- A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25- A-26-A27-A28-R1 wherein the definitions of A1 to A28 and R1 to R3 are provided for in the specification for each of formulae (I) and (II), pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising an effective amount of a compound of formula (I), that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof.

公开(公告)号：EP1624884A2

公开(公告)日：2006-02-15

申请号：EP04760052.3

申请日：2004-04-21

申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng, Xin ,  SHEN, Yeelana ,  COMSTOCK, Jeanne, Mary ,  KIM, Sun, H.

IPC分类号： A61K38/01 ,  A61K38/02 ,  A61K38/03 ,  A61K38/04 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/09 ,  A61K38/10 ,  A61K38/12 ,  A61K38/16 ,  A61K38/22 ,  A61K38/24 ,  A61K38/31 ,  C07K2/00 ,  C07K7/00 ,  C07K7/23 ,  C07K7/50 ,  C07K7/64 ,  C07K14/00

CPC分类号： C07K14/655 ,  A61K38/00 ,  A61K47/64 ,  C07K7/086 ,  C07K7/23 ,  C07K14/6555

摘要： The invention features targeted cytotoxic compounds and methods relating to their therapeutic use for the treatment of neoplasia and other conditions.