公开(公告)号：EP1100512A4

公开(公告)日：2001-10-10

申请号：EP99935854

申请日：1999-07-23

申请人： SOUTHERN RES INST

发明人： SECRIST JOHN A III ,  TIWARI KAMAL N ,  MONTGOMERY JOHN A

IPC分类号： C07H19/06 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61P35/00 ,  C07D409/04 ,  C07H19/04 ,  C07H19/12 ,  A61K31/70

CPC分类号： C07D409/04 ,  A61K31/513 ,  A61K31/53 ,  C07H19/04

摘要： Patients suffering from cancer are treated by being administered a compound represented by formula: (1), wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of formulae (IIa, IIb, IIc, IId), wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells.

摘要翻译： 通过给予式（1）表示的化合物，其中每个R分别为H或脂族或芳族酰基，治疗患有癌症的患者; A选自式（IIa，IIb，IIc，IId），其中X选自氢，氟，烷氧基，烷基，卤代烷基，烯基，卤代烯基，炔基，氨基，单烷基氨基，二烷基氨基， 氰基和硝基。 上述化合物还抑制哺乳动物细胞中的DNA复制。

公开(公告)号：EP1261350A4

公开(公告)日：2003-04-16

申请号：EP01910961

申请日：2001-02-16

申请人： SOUTHERN RES INST

发明人： MONTGOMERY JOHN A ,  FOWLER ANITA T ,  SECRIST JOHN A III

IPC分类号： C07H19/16 ,  C07H19/19

CPC分类号： C07H19/16

摘要： 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.

公开(公告)号：EP0595826A4

公开(公告)日：1996-01-10

申请号：EP92912163

申请日：1992-05-07

申请人： SOUTHERN RES INST

发明人： MONTGOMERY JOHN A ,  SECRIST JOHN A

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P35/00 ,  A61P43/00 ,  C07H19/16 ,  C07H19/19

CPC分类号： C07H19/16