公开(公告)号：EP0775117A1

公开(公告)日：1997-05-28

申请号：EP95927535.0

申请日：1995-07-31

申请人： SRI INTERNATIONAL ,  University of Glasgow ,  CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED

发明人： TRACY, Michael ,  KELSON, Andrew, B. ,  WORKMAN, Paul ,  LEWIS, Alexander, D. ,  ABOAGYE, Eric, O.

IPC分类号： A61K49 ,  C07D233 ,  C07H13 ,  C07H15

CPC分类号： C07H13/04 ,  A61K49/06 ,  C07D233/91 ,  C07H15/04

摘要： Novel agents useful for detecting hypoxic tumor cells are provided. The compounds have structural formula (I), wherein R1 and R¿2? are as defined herein. Methods of using the compounds to detect hypoxic tumor cells are also provided, as are pharmaceutical compositions formulated with the novel compounds.

公开(公告)号：EP0775117B1

公开(公告)日：2001-11-21

申请号：EP95927535.5

申请日：1995-07-31

申请人： SRI INTERNATIONAL ,  University of Glasgow ,  CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED

发明人： TRACY, Michael ,  KELSON, Andrew, B. ,  WORKMAN, Paul ,  LEWIS, Alexander, D. ,  ABOAGYE, Eric, O.

IPC分类号： C07D233/91 ,  A61K31/415 ,  C07H5/04 ,  A61K31/70

CPC分类号： C07H13/04 ,  A61K49/06 ,  C07D233/91 ,  C07H15/04

摘要： Novel agents useful for detecting hypoxic tumor cells are provided. The compounds have structural formula (I), wherein R1 and R¿2? are as defined herein. Methods of using the compounds to detect hypoxic tumor cells are also provided, as are pharmaceutical compositions formulated with the novel compounds.