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14 条记录 (耗时 0.009 秒)

    Process for the preparation of DL-phenyl-glycine amide
    1.
    发明公开
    Process for the preparation of DL-phenyl-glycine amide 失效
    Verfahren zur Herstellung von DL-苯基甘氨酰胺。

    公开(公告)号：EP0002297A2

    公开(公告)日：1979-06-13

    申请号：EP78200316.4

    申请日：1978-11-25

    申请人： STAMICARBON B.V.

    发明人： Boesten, Wilhelmus Hubertus Joseph

    IPC分类号： C07C102/06 ,  C07C103/28 ,  C07C101/18 ,  C07B20/00

    CPC分类号： C07C233/00 ,  C07C237/00

    摘要： Process for the preparation of DL-phenylglycine amide, whereby L-phenylglycine by-product is converted into an ester with an alcohol. The ester is then racemized in the presence of a concentrated strong acid, and the resulting DL-ester is converted into DL-phenylglycine amide.

    摘要翻译： 制备DL-苯基甘氨酸酰胺的方法，由此将L-苯基甘氨酸副产物用醇转化成酯。 然后将酯在浓缩的强酸存在下进行外消旋化，得到的DL-酯转化成DL-苯基甘氨酸酰胺。

    Process for the preparation of DL-phenyl-glycine amide
    5.
    发明公开
    Process for the preparation of DL-phenyl-glycine amide 失效
    制备DL-苯甲酰胺酰胺的方法

    公开(公告)号：EP0002297A3

    公开(公告)日：1979-06-27

    申请号：EP78200316

    申请日：1978-11-25

    申请人： STAMICARBON B.V.

    发明人： Boesten, Wilhelmus Hubertus Joseph

    IPC分类号： C07C102/06 ,  C07C103/28 ,  C07C101/18 ,  C07B20/00

    CPC分类号： C07C233/00 ,  C07C237/00

    摘要： Process for the preparation of DL-phenylglycine amide, whereby L-phenylglycine by-product is converted into an ester with an alcohol. The ester is then racemized in the presence of a concentrated strong acid, and the resulting DL-ester is converted into DL-phenylglycine amide.

    摘要翻译： 制备DL-苯基甘氨酸酰胺的方法，由此将L-苯基甘氨酸副产物用醇转化成酯。 然后将酯在浓缩的强酸存在下进行外消旋化，得到的DL-酯转化成DL-苯基甘氨酸酰胺。

    Process for racemizing an optically active N-benzylidene amino-acid amide
    7.
    发明公开
    Process for racemizing an optically active N-benzylidene amino-acid amide 失效
    一种用于光学活性的N-Benzylidenaminosäureamids的外消旋化过程。

    公开(公告)号：EP0199407A1

    公开(公告)日：1986-10-29

    申请号：EP86200603.8

    申请日：1986-04-10

    申请人： STAMICARBON B.V.

    发明人： Boesten, Wilhelmus Hubertus Joseph ,  Schoemaker, Hans Egbert ,  Dassen, Bernardus Henricus Nicolaas

    IPC分类号： C07B55/00 ,  C07C237/30 ,  C12P13/04 ,  C12P41/00

    CPC分类号： C12P13/04 ,  C12P13/08 ,  C12P41/007

    摘要： The invention relates to a process for racemizing an optically active N-benzylidene amino-acid amide, characterized in that a solution of the N-benzylidene amino-acid amide is mixed in a water-miscible organic solvent with at least 0.05 mole strong base per litre solution.
    The invention further relates to a process for preparing an L-amino acid by enzymatic separation of the corresponding DL-amino-acid amide with an enzyme preparation from Pseudomonas putida, in which process also unconverted D-amino-acid amide is left behind in solution, characterized in that benzaldehyde is added to the solution, during which addition a precipitate of D-N-benzylidene amino-acid amide is being formed, this precipitate is subsequently, after being separated off, dissolved in an acetone-water mixture, 0.08-0.15 mole KOH/litre solution is subsequently added, the resulting solution is stirred for 1-20 hours at 20-60 ¤C, sulphuric acid is then added until the pH of the solution is 5 and the resulting sulphuric acid salt of the DL-amino-acid amide is finally, after isolation at pH 8-10, converted into the DL-amino-acid amide and this DL-amino-acid amide is used again.

    Process for the preparation of L-alpha-amino acid and D-alpha-amino acid amide
    8.
    发明公开
    Process for the preparation of L-alpha-amino acid and D-alpha-amino acid amide 失效
    一种制备L-α-氨基酸和D-α-氨基酸酰胺的过程。

    公开(公告)号：EP0181675A1

    公开(公告)日：1986-05-21

    申请号：EP85201842.3

    申请日：1985-11-11

    申请人： STAMICARBON B.V.

    发明人： Kerkhoffs, Pieter Laurens ,  Boesten, Wilhelmus Hubertus Joseph

    IPC分类号： C12P13/04 ,  C12P13/08 ,  C12N9/80

    CPC分类号： C12N9/80 ,  C12P13/04

    摘要： @ The invention relates to a process for the preparation of L-a-amino acid and D-a-amino acid amide from DL-a-aminoacid amide by contacting the DL-a-amino acid amide in an aqueous solution with an a-amino acyl amidase containing preparation obtained from a culture of Pseudomonas putida in the presence of traces of bivalent metal ions as activator, characterized in that the aqueous solution also contains a potassium salt selected from the group consisting of potassium sulphate and potassium chloride.
    The invention further relates to a process for the preparation of a L-α-amino acid and D-α-amino acid amide starting from the corresponding aldehyde, potassium cyanide and ammoniumsulphate, subsequent treatment with a ketone and potassiumhydroxide and finally subjecting to enzymatic hydrolysis with a preparation obtained from Pseudomonas putida.