专利检索 ap:("START TECHNOLOGY PARTNERSHIP") AND inv:"WEISS, Benjamin" 第 1 页

1.

发明公开
ADMINISTRATION OF OLIGONUCLEOTIDES ANTISENSE TO DOPAMINE RECEPTOR MRNA FOR DIAGNOSIS AND TREATMENT OF NEUROLOGICAL PATHOLOGIES 失效
标题翻译：多巴胺受体mRNA反SENSEN寡核苷酸的神经系统病变的诊断和治疗。

公开(公告)号：EP0673252A1

公开(公告)日：1995-09-27

申请号：EP94904446.0

申请日：1993-12-14

申请人： START TECHNOLOGY PARTNERSHIP

发明人： WEISS, Benjamin

IPC分类号： G01N33 , A61K31 , A61P25 , C07H21 , C12N15 , C12Q1

CPC分类号： A61K31/70 , C07H21/00 , C12N15/1138

摘要： A method and pharmaceutical preparation are provided for diagnosing and treating pathological conditions related to a dopamine receptor abnormality. The method comprises administering to a patient having such a pathological condition an oligonucleotide antisense to one or more RNA molecules encoding one of the several dopamine receptors. The antisense oligonucleotides bind specifically to expression-controlling sequences of such RNA molecules, thereby selectively controlling expression of one or more dopamine receptor subtypes, and alleviating the pathological conditions related to their expression.