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1.发明公开ADMINISTRATION OF OLIGONUCLEOTIDES ANTISENSE TO DOPAMINE RECEPTOR MRNA FOR DIAGNOSIS AND TREATMENT OF NEUROLOGICAL PATHOLOGIES. 失效多巴胺受体mRNA反SENSEN寡核苷酸的神经系统病变的诊断和治疗。
公开(公告)号：EP0673252A4
公开(公告)日：1998-07-15
申请号：EP94904446
申请日：1993-12-14
发明人： WEISS BENJAMIN
IPC分类号： G01N33/566 , A61K31/70 , A61P25/00 , A61P25/18 , C07H21/00 , C07H21/04 , C12N15/09 , C12N15/113 , C12Q1/68 , A61K38/00 , A61K48/00
CPC分类号： A61K31/70 , C07H21/00 , C12N15/1138
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公开(公告)号：EP0721464A1
公开(公告)日：1996-07-17
申请号：EP94928025.0
申请日：1994-08-31
发明人： CUNNINGHAM, Timothy, J. , HAUN, Forest , EAGLESON, Katie, L. , LEVITT, Pat, R. , KENNEDY, Sarah, E.
IPC分类号： C12N15 , A61K9 , A61K38 , A61K39 , A61P25 , A61P43 , C07K4 , C07K14 , C07K16 , C12P21 , C12R1
CPC分类号： C07K14/475 , A61K38/00
摘要： A neuron regulatory factor (NRF), derived from cells of the central nervous system, is provided. NRF comprises a large polypeptide or complex of polypeptides that is antigenically distinct from several other known neurotrophic or neuron regulatory factors, and is capable of promoting survival and neurite outgrowth of cultured neurons in vitro, and preventing neuron degeneration and promoting neuron survival in vivo. NRF exerts a neurotrophic effect in a concentration-dependent manner on a variety of distinct neuron populations, and is administered as a pharmaceutical preparation to patients suffering from neuron damage or neurodegenerative disease in an amount effective to facilitate survival and recovery of damaged neurons.
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4.发明公开ADMINISTRATION OF OLIGONUCLEOTIDES ANTISENSE TO DOPAMINE RECEPTOR MRNA FOR DIAGNOSIS AND TREATMENT OF NEUROLOGICAL PATHOLOGIES 失效多巴胺受体mRNA反SENSEN寡核苷酸的神经系统病变的诊断和治疗。
公开(公告)号：EP0673252A1
公开(公告)日：1995-09-27
申请号：EP94904446.0
申请日：1993-12-14
发明人： WEISS, Benjamin
CPC分类号： A61K31/70 , C07H21/00 , C12N15/1138
摘要： A method and pharmaceutical preparation are provided for diagnosing and treating pathological conditions related to a dopamine receptor abnormality. The method comprises administering to a patient having such a pathological condition an oligonucleotide antisense to one or more RNA molecules encoding one of the several dopamine receptors. The antisense oligonucleotides bind specifically to expression-controlling sequences of such RNA molecules, thereby selectively controlling expression of one or more dopamine receptor subtypes, and alleviating the pathological conditions related to their expression.
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