专利检索 ap:("STRIKE BIO INC") AND inv:"NEMUNAITIS JOHN J" 第 1 页

1.

发明公开
BI-FUNCTIONAL SHORT-HAIRPIN RNA (BI-SHRNA) SPECIFIC FOR SINGLE-NUCLEOTIDE KRAS MUTATIONS 审中-公开
标题翻译：对于单核苷酸KRAS突变特异性双官能SHORT-发夹RNA（shRNA-BI）

公开(公告)号：EP2847333A4

公开(公告)日：2015-12-16

申请号：EP13788485

申请日：2013-05-09

申请人： STRIKE BIO INC

发明人： RAO DONALD , WANG ZHAOHUI , NEMUNAITIS JOHN J , SENZER NEIL

IPC分类号： C12N15/113 , A61K9/127 , A61K48/00 , A61P35/00 , B82Y5/00 , C12N15/85

CPC分类号： C12N15/1135 , A61K9/127 , A61K31/713 , A61K45/06 , C12N2310/14 , C12N2310/51 , C12N2310/531 , C12N2310/533 , C12N2320/32 , C12N2320/50 , C12Q1/6897

摘要： The present invention includes compositions and methods for making and using a bifunctional shRNAs capable of reducing an expression of a K-ras gene, e.g., a mutated K-ras gene, wherein at least one target site sequence of the bifunctional RNA molecule is located within the K-ras gene and wherein the bifunctional RNA molecule is capable of activating a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of K-ras.