公开(公告)号：EP0322800A1

公开(公告)日：1989-07-05

申请号：EP88121599.0

申请日：1988-12-23

申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED

发明人： Ohashi, Naohito ,  Fujimoto, Koji ,  Mori, Kazuo ,  Tanaka, Yoshihiro ,  Saji, Ikutaro ,  Nishizawa, Toshio

IPC分类号： C07D249/08 ,  C07D233/60

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： A process for preparing sulfone derivatives of the formula:
wherein R¹ and R² are each a hydrogen atom, a lower alkyl group or a substituted or unsubstituted cyclo(lower)alkyl, cyclo(lower)alkylmethyl, lower alkenyl, heterocyclic, aryl or ar(lower)alkyl group, R⁴, R⁵, R⁶ and R⁷ are each a hydrogen atom, a lower alkyl group, a lower alkenyl group or a substituted or unsubstituted aryl grcup and Az is a 1,2,4- or 1,3,4-triazole or imidazole ring, which comprises subjecting a sulfide or sulfoxide compound of the formula:
wherein R¹, R², R⁴, R⁵, R⁶, R⁷ and Az are each as defined above and n is an integer of 0 or 1 to oxidation with an oxidizing agent in the presence of a metal catalyst.

摘要翻译： 制备下式的砜衍生物的方法：其中R 1和R 2各自为氢原子，低级烷基或取代或未取代的环（低级）烷基，环（低级）烷基甲基， 低级烯基，杂环，芳基或芳（低级）烷基，R 4，R 5，R 6和R 7各自为氢原子，低级烷基，低级烯基或 取代或未取代的芳基基团，并且Az是1,2,4-或1,3,4-三唑或咪唑环，其包括使下式的硫化物或亚砜化合物：其中R 1， R 2，R 4，R 5，R 6，R 7和A 11各自如上所定义，n是0或1的整数，在金属存在下用氧化剂氧化 催化剂。