公开(公告)号：EP0706999A1

公开(公告)日：1996-04-17

申请号：EP94917158.1

申请日：1994-06-06

申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED

发明人： IKEDA, Yoshiharu ,  UEKI, Yasuyuki ,  NISHIHARA, Toshio, Studio In Dekijimaeki 247 ,  KAMIKAWA, Yumiko

IPC分类号： C07D211/34 ,  C07D211/46 ,  C07D401/14 ,  A61K31/445

CPC分类号： C07D401/14 ,  C07D207/34 ,  C07D207/36 ,  C07D211/46

摘要： The present invention relates to an novel dipiperidine derivative represented by formula (1), or a pharmaceutically acceptable salt thereof;

wherein R¹ represents a hydrogen atom or a lower alkyl group; Y represents a single bond or an oxygen atom; n represents 1, 2 or 3; W represents a methylene group or an oxygen atom; R² represents a hydrogen atom or a carboxyl modifying group which can be eliminated in vivo; X¹ and X³ are the same or different and each represents a hydrogen atom or a lower alkyl group.
This compound is useful as platelet aggregation inhibitors, cancer metastasis inhibitors, wound remedies or bone resorption inhibitors.

摘要翻译： 本发明涉及由式（1）表示的新型二哌啶衍生物或其药学上可接受的盐; 其中R 1代表氢原子或低级烷基; Y代表单键或氧原子; n代表1,2或3; W代表亚甲基或氧原子; R 2表示可以在体内消除的氢原子或羧基修饰基团; X 1和X 3相同或不同，各自代表氢原子或低级烷基。 该化合物可用作血小板聚集抑制剂，癌症转移抑制剂，伤口治疗剂或骨吸收抑制剂。