公开(公告)号：EP1541569B1

公开(公告)日：2010-05-12

申请号：EP03741391.1

申请日：2003-07-15

申请人： SUMITOMO SEIKA CHEMICALS CO., LTD.

发明人： KOGAMI, K. Fine Chem. Res. Lab. Sumitomo Seika ,  HAYASHIZAKA, N. Fine Chem. Res. Lab. Sumitomo lab. ,  SATAKE, S. Fine Chem. Res. Lab. Sumitoma Seika ,  FUSEYA, I. Sumitomo Seika Chemicals Co., LTD ,  KAGANO, H. Sumitomo Seika Chemicals Co., Ltd.

IPC分类号： C07D333/20 ,  C07D333/22

CPC分类号： C07D333/22 ,  C07D333/20

摘要： A process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine represented by the general formula (2): (2) (wherein R represents C1-4 alkyl), characterized by reducing a (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by the general formula (1): (1) (wherein R is the same as the above). By the process, an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine useful as an intermediate for various medicines can be industrially and easily produced at low cost.

公开(公告)号：EP1541569A1

公开(公告)日：2005-06-15

申请号：EP03741391.1

申请日：2003-07-15

申请人： SUMITOMO SEIKA CHEMICALS CO., LTD.

发明人： KOGAMI, K. Fine Chem. Res. Lab. Sumitomo Seika ,  HAYASHIZAKA, N. Fine Chem. Res. Lab. Sumitomo lab. ,  SATAKE, S. Fine Chem. Res. Lab. Sumitoma Seika ,  FUSEYA, I. Sumitomo Seika Chemicals Co., LTD ,  KAGANO, H. Sumitomo Seika Chemicals Co., Ltd.

IPC分类号： C07D333/20 ,  C07D333/22

CPC分类号： C07D333/22 ,  C07D333/20

摘要： The present invention provides a process for producing an N -monoalkyl-3-hydroxy-3-(2-thienyl)propanamine represented by General Formula (2):
wherein R is C 1-4 alkyl, comprising the step of reducing ( Z )- N -monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1):
wherein R is as defined above. According to the present invention, an N -monoalkyl-3-hydroxy-3-(2-thienyl)propanamine which is for use as an intermediate for various pharmaceuticals can be produced in an industrially inexpensive and easy manner.

摘要翻译： 本发明提供一种制备由通式（2）表示的N-单烷基-3-羟基-3-（2-噻吩基）丙胺的方法：其中R是C 1-4烷基的，其包括将 Z）-N-单烷基-3-氧代-3-（2-噻吩基）丙烯胺，其通式如下：其中R如上定义。 根据本发明，用作各种药物的中间体的N-单烷基-3-羟基-3-（2-噻吩基）丙胺可以以工业上便宜且容易的方式制备。