公开(公告)号：EP3128892A4

公开(公告)日：2018-05-09

申请号：EP15773739

申请日：2015-04-06

申请人： SURGISENSE CORP

发明人： ZAND JASON M ,  FISCHER GREGORY S ,  KNOWLES JUSTIN T

IPC分类号： A61B1/04 ,  A61B1/06

CPC分类号： A61B5/14556 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/005 ,  A61B1/0125 ,  A61B1/018 ,  A61B1/043 ,  A61B1/0676 ,  A61B5/0035 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/015 ,  A61B5/1459 ,  A61B2560/0247

摘要： Apparatus, systems, and methods are provided that generate in vivo maps of oxygenation measurements of biological tissue. These may include surgical instruments and stand-alone imaging systems with incorporated oxygen sensing capability. Oxygenation maps can be determined via fluorescent or phosphorescent lifetime imaging of an injectable probe with an oxygen-dependent optical response. Probe configuration and methods and apparatus of injecting the probe into the tissue are provided. Methods and apparatus for temperature compensation of temperature-dependent lifetime measurements are provided to improve oxygenation measurement accuracy. Oxygen maps may be registered with visible light images to assist in assessing tissue viability or localize anomalies in the tissue. Resulting oxygen images may be used for various applications including, but not limited to, guiding surgical procedures such as colorectal resection through use of intraoperative sensing, enhanced endoscopic imaging for identifying suspect lesions during colonoscopy, and external imaging of tissue such as assessing peripheral vascular disease.