公开(公告)号：EP0866708A1

公开(公告)日：1998-09-30

申请号：EP96941406.0

申请日：1996-11-15

申请人： SYNAPTIC PHARMACEUTICAL CORPORATION ,  MERCK & CO., INC.

发明人： NAGARATHNAM, Dhanapalan ,  WONG, Wai, C. ,  MIAO, Shou, Wu ,  PATANE, Michael, A. ,  GLUCHOWSKI, Charles

IPC分类号： A61K31 ,  A61P3 ,  A61P9 ,  A61P15 ,  A61P27 ,  C07D239 ,  C07D401 ,  C07D491

CPC分类号： C07D239/22 ,  C07D401/12 ,  C07D491/04

摘要： This invention is directed to dihydropyrimidine compounds which are selective antagonists for human α1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of begnin prostatic hyperplasia, impotency, cardiac arrythmia and for the treatment of any disease where the antagonism of the α1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.