公开(公告)号：EP3052634A4

公开(公告)日：2017-06-28

申请号：EP14851126

申请日：2014-10-03

申请人： SYNTHETIC GENOMICS INC

发明人： AJJAWI IMAD ,  AQUI MOENA ,  SORIAGA LEAH

IPC分类号： C12N15/82

CPC分类号： C07K14/405 ,  C12N1/12 ,  C12N15/79 ,  C12N15/8261 ,  C12P1/00 ,  C12P7/64 ,  C12P7/649 ,  C12P13/04 ,  C12P19/00 ,  C12P19/34 ,  C12P21/00 ,  Y02A40/146 ,  Y02E50/13

摘要： The disclosure generally relates to methods and materials for modulating cell productivity. In particular, the present disclosure provides polynucleotides encoding transcription factor proteins that when overexpressed in microorganisms result in increased in productivity, such as increased biomass productivity. Also disclosed are methods of using the genetically engineered host strains to modulate or increase productivity of host cells such as, for example, algal or heterokont cells. Genetically engineered host cells, such as algal and heterokont cells having increased biomass productivity and bioproducts derived from such host cells are also disclosed.

摘要翻译： 本公开总体涉及用于调节细胞生产力的方法和材料。 具体而言，本公开提供编码转录因子蛋白质的多核苷酸，所述转录因子蛋白质在微生物中过表达时导致生产力增加，例如生物量生产力提高。 还公开了使用基因工程宿主菌株来调节或增加宿主细胞例如藻类或异质细胞的生产力的方法。 还公开了基因工程宿主细胞，例如具有增加的生物生产力的藻类和异质细胞以及源自这种宿主细胞的生物产品。

公开(公告)号：EP3090041A4

公开(公告)日：2017-06-07

申请号：EP14876326

申请日：2014-12-30

申请人： SYNTHETIC GENOMICS INC

发明人： AJJAWI IMAD ,  AQUI MOENA ,  CHAVEZ-TORRES CARLOS

IPC分类号： C12N1/12 ,  C07K14/405 ,  C12N15/79 ,  C12N15/82 ,  C12P7/64

CPC分类号： C07K14/405 ,  C12N15/79 ,  C12N15/8247 ,  C12N15/8261 ,  C12P7/6463 ,  Y02A40/146

摘要： The disclosure generally relates to methods and materials for modulating cell productivity. In particular, the present disclosure provides polynucleotides and polypeptides that when overexpressed in microorganisms result in increased in productivity, such as increased biomass productivity. Also disclosed are methods of using the polynucleotides and polypeptides to modulate or increase productivity of host cells such as, for example, algal or heterokont cells. Genetically engineered host cells, such as algal and heterokont cells having increased biomass productivity and bioproducts derived from such host cells are also disclosed.

摘要翻译： 本公开总体涉及用于调节细胞生产力的方法和材料。 特别地，本公开提供了当在微生物中过表达时导致生产力增加，例如生物量增加的多核苷酸和多肽。 还公开了使用多核苷酸和多肽来调节或增加宿主细胞例如藻类或异形细胞的生产力的方法。 还公开了基因工程宿主细胞，例如具有增加的生物生产力的藻类和异质细胞以及源自这种宿主细胞的生物产品。