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    Blood cell analyzer
    1.
    发明公开
    Blood cell analyzer 审中-公开
    血细胞分析仪

    公开(公告)号：EP2902769A3

    公开(公告)日：2015-09-02

    申请号：EP15152465.9

    申请日：2015-01-26

    申请人： SYSMEX CORPORATION

    发明人： Kimura, Konobu ,  Uchihashi, Kinya

    IPC分类号： G01N15/14 ,  G01N15/10 ,  G01N15/00

    CPC分类号： G01N15/1429 ,  G01N15/1459 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1477

    摘要： A blood cell analyzer comprises specimen preparation means for preparing a first measurement specimen and for preparing a second measurement specimen, optical detection means for detecting light emitted from each particle contained in each of the first measurement specimen and the second measurement specimen, control means for performing first classification based on the first detection signals and counting a first number of white blood cells and for performing second classification based on the second detection signals and counting a second number of white blood cells, and output means. In accordance with a result of detection of particles whose first detection signals each have a waveform having a width being greater than or equal to a predetermined value, the control means causes the output means to output either one of the first number of white blood cells and the second number of white blood cells, as the number of white blood cells of the blood sample.

    Blood analyzer, blood analysis method, hemolytic agent and staining agent
    3.
    发明公开
    Blood analyzer, blood analysis method, hemolytic agent and staining agent 有权
    Blutanalysator，Blutanalyseverfahren，HämolytikumundFärbemittel

    公开(公告)号：EP2889620A1

    公开(公告)日：2015-07-01

    申请号：EP14198316.3

    申请日：2009-04-28

    申请人： Sysmex Corporation

    发明人： Matsumoto, Hideaki ,  Uchihashi, Kinya ,  Itose, Yuji ,  Konishi, Aya ,  Yoshida, Ayumu

    IPC分类号： G01N33/48 ,  G01N33/49 ,  G01N33/72

    CPC分类号： C12Q1/68 ,  G01N33/5094 ,  G01N33/56905 ,  G01N2333/44 ,  Y02A50/58

    摘要： This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and a group of the others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into malaria-infected red blood cells and a group of the others on the basis of fluorescent information and scattered light information generated by the light information generation portion. Different dilution magnifications of the hemolytic agent as regards first and second sample are present in product and method to achieve the differentiation between malaria infected red blood cells and different types of white blood cells and count the infected cells

    摘要翻译： 该血液分析装置包括制备含有血液试样和溶血剂的第一测定试样的试样调制部和含有血液试样的第二测定试样，与溶血剂相同的溶血剂和染色剂，以及将白血球分类的对照部 基于荧光信息和由光信息产生部生成的两种类型的散射光信息将第一测量样品中的细胞分成至少四组单核细胞，嗜中性粒细胞，嗜酸性粒细胞和其他组，并在第二组中对血细胞进行分类 基于由光信息生成部生成的荧光信息和散射光信息，将测定样品分配到疟疾感染的红细胞和其他组中。 在产品和方法中存在关于第一和第二样品的溶血剂的不同稀释倍率，以实现疟疾感染的红细胞和不同类型的白细胞之间的分化并计数感染的细胞

    Method for analyzing blood cells and blood cell analyzer
    4.
    发明公开
    Method for analyzing blood cells and blood cell analyzer 审中-公开
    Verfahren zur分析von Blutzellen und Blutzellenanalysegertt

    公开(公告)号：EP2735859A2

    公开(公告)日：2014-05-28

    申请号：EP13193634.6

    申请日：2013-11-20

    申请人： SYSMEX CORPORATION

    发明人： Kimura, Konobu ,  Uchihashi, Kinya

    IPC分类号： G01N15/14 ,  G01N15/10 ,  G01N15/00

    摘要： A method for analyzing blood cells includes: preparing a measurement specimen for classifying white blood cells, by mixing a sample with a reagent in order to hemolyze red blood cells contained in the sample and to fluorescently stain nucleic acid in white blood cells contained in the sample; detecting, by flowing the prepared measurement specimen in a flow cell, fluorescence emitted from each blood cell in the measurement specimen and two types of scattered light at respective different angles, and obtaining a fluorescence signal and two types of scattered light signals; and classifying the white blood cells into at least four groups and detecting neoplastic lymphocytes, by performing analysis using at least three types of parameters based on the obtained fluorescence signal and two types of scattered light signals.

    摘要翻译： 一种分析血液细胞的方法包括：通过将样品与试剂混合以制备样品中含有的红血细胞，并使荧光染色样品中含有的白细胞的核酸，制备用于分类白细胞的测定试样 ; 通过使准备好的测定试样在流动池中流动，通过使测定试样中的各血细胞发出的荧光和各种不同角度的两种散射光进行荧光检测，得到荧光信号和两种散射光信号; 并通过基于获得的荧光信号和两种类型的散射光信号使用至少三种参数进行分析，将白细胞分成至少四组并检测肿瘤淋巴细胞。

    Blood cell analyzer
    7.
    发明公开
    Blood cell analyzer 审中-公开
    血细胞分析仪

    公开(公告)号：EP2902769A2

    公开(公告)日：2015-08-05

    申请号：EP15152465.9

    申请日：2015-01-26

    申请人： SYSMEX CORPORATION

    发明人： Kimura, Konobu ,  Uchihashi, Kinya

    IPC分类号： G01N15/14 ,  G01N15/10 ,  G01N15/00

    CPC分类号： G01N15/1429 ,  G01N15/1459 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1477

    摘要： A blood cell analyzer comprises specimen preparation means for preparing a first measurement specimen and for preparing a second measurement specimen, optical detection means for detecting light emitted from each particle contained in each of the first measurement specimen and the second measurement specimen, control means for performing first classification based on the first detection signals and counting a first number of white blood cells and for performing second classification based on the second detection signals and counting a second number of white blood cells, and output means. In accordance with a result of detection of particles whose first detection signals each have a waveform having a width being greater than or equal to a predetermined value, the control means causes the output means to output either one of the first number of white blood cells and the second number of white blood cells, as the number of white blood cells of the blood sample.

    摘要翻译： 本发明提供一种血细胞分析装置，其特征在于，具备：准备第一测定试样和准备第二测定试样的试样调制单元;检测从第一测定试样和第二测定试样各自中含有的各粒子发出的光的光学检测单元; 根据第一检测信号进行第一分类并对第一数量的白细胞进行计数，并根据第二检测信号进行第二分类并对第二数量的白细胞进行计数;以及输出装置。 根据其第一检测信号各自具有宽度大于或等于预定值的波形的颗粒的检测结果，控制装置使输出装置输出第一数量的白血细胞和 第二数量的白血细胞，作为血样的白血细胞的数量。

    Container storing washing solution used for blood analyzer
    8.
    发明公开
    Container storing washing solution used for blood analyzer 审中-公开
    对于使用洗涤液与血液分析仪的储存罐

    公开(公告)号：EP2644273A2

    公开(公告)日：2013-10-02

    申请号：EP12197222.8

    申请日：2012-12-14

    申请人： SYSMEX CORPORATION

    发明人： Mori, Yusuke ,  Uchihashi, Kinya ,  Mizuno, Yumiko

    IPC分类号： B01L3/14 ,  G01N35/10

    摘要： This container storing a washing solution for a blood analyzer includes a container body made of thermoplastic resin resistant against a chlorine-based washing solution and provided with an opening on an upper portion, a chlorine-based washing solution stored in the container body, and a multilayer film covering the opening. The multilayer film includes a seal layer heat-sealed to the container body thereby blocking the opening and a gas barrier layer arranged on the outer side of the seal layer.

    摘要翻译： 此容器存储用于血液分析仪的洗涤溶液包括由热塑性树脂对基于氯的清洗液耐并在开口上上部，存储在所述容器主体中的基于氯的清洗液提供的的容器主体，和一个 多层膜覆盖该开口。 的多层薄膜的密封层包括热密封到容器主体从而阻断开口和布置在所述密封层的外侧的气体阻隔层。

    Diluting reagent and method providing time-independent consistency in mean corpuscular volume assays
    9.
    发明公开
    Diluting reagent and method providing time-independent consistency in mean corpuscular volume assays 有权
    稀释剂和程序在试验建立的时间无关的一致性Mittlereteilchenvolumen

    公开(公告)号：EP1058114A3

    公开(公告)日：2001-12-12

    申请号：EP00304578.8

    申请日：2000-05-30

    申请人： Sysmex Corporation

    发明人： Houwen, Berend ,  Uchihashi, Kinya ,  Hamaguchi, Yukio ,  Mast, Rolf

    IPC分类号： G01N33/49 ,  G01N33/80

    CPC分类号： G01N33/5094 ,  G01N15/12 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/108331 ,  Y10T436/2525 ,  Y10T436/25625

    摘要： A method for MCV assay comprising the process of: treating a blood sample with an anti-coagulant agent immediately post-drawing; diluting the blood sample treated with the anti-coagulant agent at up to at least 72 hours post blood-drawing with a reagent solution containing a predetermined surfactant at a predetermined osmotic concentration, thereby compelling a morphological change in the blood sample RBCs; and assaying the blood sample in a particle analyzer. The reagent includes a nonionic surfactant, a salt for adjusting osmotic pressure, and water, and has an osmotic pressure (π) of approximately 150-400 mOsm/kg and a pH of 6.0-8.5. The surfactant is present in a 0.0005% to 0.5% concentration and has a hydrophile-lipophile balance (HLB) of 10-20.

    摘要翻译： 一种用于MCV分析方法，包括以下过程：处理血液样品与抗凝血剂以立即拉伸柱; 稀释用抗凝结剂以高达至少72小时处理的血液样品后采血用试剂溶液含有在预定渗透浓度的预定表面活性剂，从而迫使在所述血液样品的红细胞的形态变化; 并测定在粒度分析仪的血液样品。 该试剂包括非离子表面活性剂，用于调节渗透压的盐和水，并具有大约150-400毫渗透摩尔浓度/千克渗透压（PI）和pH为6.0-8.5。 所述表面活性剂存在于0.0005％至0.5％的浓度，并且具有10-20的亲水亲油平衡（HLB）。