公开(公告)号：EP1854788B8

公开(公告)日：2012-12-26

申请号：EP06714409.7

申请日：2006-02-23

申请人： Sagami Chemical Research Institute ,  Japan Finechem Company, Inc.

发明人： AIHARA, Hidenori ,  YOKOTA, Wakako ,  YAMAKAWA, Tetsu ,  HIRAI, Kenji

IPC分类号： C07D231/14

CPC分类号： C07D231/14

公开(公告)号：EP2975040A1

公开(公告)日：2016-01-20

申请号：EP14765633.4

申请日：2014-03-14

申请人： Sagami Chemical Research Institute ,  Kaken Pharmaceutical Co., Ltd.

发明人： KOBAYASHI, Osamu ,  NIIKURA, Naoko ,  INOUE, Tomoko ,  MIZUTA, Satoshi ,  TAKATSUNA, Reiko ,  HIRAI, Kenji ,  SHIROUZU, Kentaro ,  OBATA, Miyoo

IPC分类号： C07D487/04 ,  A01N43/90 ,  A01P13/02 ,  C07D498/04

CPC分类号： C07D498/04 ,  A01N43/90 ,  A01N47/06 ,  C07D487/04

摘要： Provided are a polycyclic pyrazolinone derivative indicated by general formula (1) (in the formula, R 1 , X 1 , X 2 , X 3 , and Y indicate the definitions provided in the Specification) and a herbicide comprising same as effective component thereof.

摘要翻译： 提供通式（1）表示的多环吡唑啉酮衍生物（式中，R 1，X 1，X 2，X 3，Y表示本说明书中提供的定义），和含有与其有效成分相同的除草剂。

公开(公告)号：EP1854788A1

公开(公告)日：2007-11-14

申请号：EP06714409.7

申请日：2006-02-23

申请人： SAGAMI CHEMICAL RESEARCH CENTER ,  Japan Finechem Company, Inc.

发明人： AIHARA, Hidenori ,  YOKOTA, Wakako ,  YAMAKAWA, Tetsu ,  HIRAI, Kenji

IPC分类号： C07D231/14

CPC分类号： C07D231/14

摘要： In a process for producing 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylate (3) by a reaction of 2-alkoxymethylenefluoroacylacetate (1) and hydrazine (2), the reaction is conducted in the presence of a base and water, to produce 1-substituted-3-fluoroalkylpyrazole-4-carboxylate (3) with high selectivity and yield. This novel process enables to produce 1-substituted-3-fluoroalkylpyrazole-4-carboxylate (3), which is useful as an intermediate for pharmaceuticals and agrochemicals, with high selectivity and yield by simple and safe operations.

摘要翻译： 在通过2-烷氧基甲基三氟酰基乙酸酯（1）和肼（2）的反应制备1-取代-3-氟烷基 - 吡唑-4-羧酸酯（3）的方法中，反应在碱和水的存在下进行， 以高选择性和产率制备1-取代-3-氟代烷基吡唑-4-羧酸酯（3）。 该新方法能够通过简单和安全的操作产生具有高选择性和产率的1-取代-3-氟烷基吡唑-4-羧酸酯（3），其可用作药物和农用化学品的中间体。

公开(公告)号：EP1854788B1

公开(公告)日：2012-06-13

申请号：EP06714409.7

申请日：2006-02-23

申请人： SAGAMI CHEMICAL RESEARCH CENTER ,  Japan Finechem Company, Inc.

发明人： AIHARA, Hidenori ,  YOKOTA, Wakako ,  YAMAKAWA, Tetsu ,  HIRAI, Kenji

IPC分类号： C07D231/14

CPC分类号： C07D231/14

摘要： Disclosed is a method for producing 1-substituted-3-fluoroalkyl pyrazole-4-carboxylate (3) through a reaction between 2-alkoxymethylene fluoroacyl acetate (1) and a hydrazine (2). By performing the reaction in the presence of a base and water, 1-substituted-3-fluoroalkyl pyrazole-4- carboxylate (3) can be highly selectively produced with high yield. This novel method enables to highly selectively produce 1-substituted-3-fluoroalkyl pyrazole-4- carboxylate (3), which is useful as an intermediate for pharmaceutical and agrichemical products, with high yield by simple and safe operations.