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    USE OF METHYLNALTREXONE TO ATTENUATE TUMOR PROGESSION
    2.
    发明公开
    USE OF METHYLNALTREXONE TO ATTENUATE TUMOR PROGESSION 审中-公开

    公开(公告)号：EP3718404A1

    公开(公告)日：2020-10-07

    申请号：EP19211300.9

    申请日：2015-10-16

    申请人： Salix Pharmaceuticals, Inc. ,  The University of Chicago

    发明人： MOSS, Jonathan ,  JOHNSON, Lorin K.

    IPC分类号： A01N43/42 ,  A61P35/00

    摘要： Presented herein are methods for preventing or treating tumor growth, tumor metastasis and/or abnormal proliferation of tumor cells in a subject, wherein the methods involve administration of a pharmaceutical composition comprising methylnaltrexone. Also presented herein are methods for inhibiting or slowing the growth of a tumor in a subject, wherein the methods include selecting a subject who is a suitable candidate for treatment with methylnaltrexone, and administering a composition comprising methylnaltrexone to the subject.

    USE OF METHYLNALTREXONE TO ATTENUATE TUMOR PROGRESSION
    3.
    发明公开
    USE OF METHYLNALTREXONE TO ATTENUATE TUMOR PROGRESSION 有权
    甲基半乳聚糖用于减轻肿瘤进展

    公开(公告)号：EP3206491A1

    公开(公告)日：2017-08-23

    申请号：EP15851308.5

    申请日：2015-10-16

    申请人： Salix Pharmaceuticals, Inc. ,  The University of Chicago

    发明人： MOSS, Jonathan ,  JOHNSON, Lorin K.

    IPC分类号： A01N43/42

    摘要： Presented herein are methods for preventing or treating tumor growth, tumor metastasis and/or abnormal proliferation of tumor cells in a subject, wherein the methods involve administration of a pharmaceutical composition comprising methylnaltrexone. Also presented herein are methods for inhibiting or slowing the growth of a tumor in a subject, wherein the methods include selecting a subject who is a suitable candidate for treatment with methylnaltrexone, and administering a composition comprising methylnaltrexone to the subject.

    摘要翻译： 本文提供了用于预防或治疗受试者中肿瘤生长，肿瘤转移和/或肿瘤细胞的异常增殖的方法，其中所述方法包括施用包含甲基纳曲酮的药物组合物。 本文还提供了用于抑制或减缓受试者中肿瘤生长的方法，其中所述方法包括选择适合用甲基纳曲酮治疗的候选者，并将包含甲基纳曲酮的组合物施用于受试者。

    USE OF 2-HYDROXY-5-PHENYLAZOBENZOIC ACID DERIVATIVES AS COLON CANCER CHEMOPREVENTATIVE AND CHEMOTHERAPEUTIC AGENTS
    4.
    发明公开
    USE OF 2-HYDROXY-5-PHENYLAZOBENZOIC ACID DERIVATIVES AS COLON CANCER CHEMOPREVENTATIVE AND CHEMOTHERAPEUTIC AGENTS 失效
    用2-羟基-5- phenylazobenzoic衍生物用于预防CHEMO作为活性成分和结肠癌的化疗

    公开(公告)号：EP0738152A1

    公开(公告)日：1996-10-23

    申请号：EP95907293.0

    申请日：1995-01-06

    申请人： SALIX PHARMACEUTICALS, INC.

    发明人： JOHNSON, Lorin K. ,  SLEISENGER, Marvin H.

    IPC分类号： A61K31 ,  A61P35 ,  A61P43

    CPC分类号： A61K31/655

    摘要： The present invention provides a method of colon cancer chemoprevention or chemotherapy comprising administering to an individual suffering from colon cancer or at risk to develop colon cancer a pharmaceutical composition comprising an effective amount of a 2-hydroxy-5-phenylazobenzoic acid derivative or an ester of an active metabolite or an oxidation product of an active metabolite thereof, or a pharmacologically acceptable salt of the 2-hydroxy-5-phenylazobenzoic acid derivative or an ester or an active metabolite or an oxidation product of an active matabolite thereof.