Azetidinone derivatives useful in the preparation of carbapenem antibiotics
    1.
    发明公开
    Azetidinone derivatives useful in the preparation of carbapenem antibiotics 失效
    Azetidinonderivate zur Herstellung von Carbapenem-Antibiotika

    公开(公告)号:EP0845459A1

    公开(公告)日:1998-06-03

    申请号:EP98103209.7

    申请日:1992-06-01

    摘要: Compounds of formula (Ia):
    in which: R 1 represents a hydrogen atom or a hydroxy-protecting group; R 2 represents a methyl group; R 3 represents a phenyl group which has a 2-substituent of formula -CYNR 5 R 6 and no further substituent or has one alkyl substituent, wherein Y represents an oxygen or sulphur atom, and R 5 and R 6 are the same or different and each represents an alkyl group, an aryl group, or R 5 and R 6 together with the nitrogen atom to which they are attached form a heterocyclic group; R 4 represents a hydrogen atom or an amino-protecting group; and Z represents a sulphur atom or an oxygen atom,
    are valuable intermediates in the preparation of carbapenem compounds and retain a desirable configuration during conversion to such carbapenem compounds.

    摘要翻译: 式(Ia)化合物:其中:R 1表示氢原子或羟基保护基; R 2表示甲基; R 3表示具有式-CYNR 5 R 6的2-取代基且不具有另外的取代基或具有一个烷基取代基的苯基,其中Y表示氧或硫原子,R 5和 R 6相同或不同,各自表示烷基,芳基或R 5和R 6与它们所连接的氮原子一起形成杂环基; R 4表示氢原子或氨基保护基; Z表示硫原子或氧原子,是制备碳青霉烯化合物的有价值的中间体,并且在转化成这种碳青霉烯化合物期间保持所需的构型。