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公开(公告)号：EP2764309B1
公开(公告)日：2016-11-23
申请号：EP12769021.2
申请日：2012-10-04
申请人： Sanofi Pasteur SA
摘要： The invention relates to freeze-drying, and more specifically to the production of freeze-dried particles as bulkware. One embodiment of a process line (300) for the production of freeze-dried particles under closed conditions comprises at least the following separate devices: A spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles; and a bulk freeze-dryer (304) for freeze drying the particles; wherein a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304), and for the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for closed operation.
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公开(公告)号：EP2764310A1
公开(公告)日：2014-08-13
申请号：EP12769022.0
申请日：2012-10-04
申请人： Sanofi Pasteur SA
IPC分类号： F26B5/06
摘要： A rotary drum (302) for use within a vacuum chamber (212) in a vacuum freeze-dryer (204) for the bulkware production of freeze-dried particles is provided. The drum (302) is in open communication with the vacuum chamber (212) and comprises a main section (304) terminated by a front plate (306) and a rear plate (308), the rear plate (308) is adapted for connection with a rotary supporting shaft (312) for rotary support of the drum (302), and the rear plate (308) is permeable for sublimation vapor from freeze-drying the particles.
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公开(公告)号：EP2764309A1
公开(公告)日：2014-08-13
申请号：EP12769021.2
申请日：2012-10-04
申请人： Sanofi Pasteur SA
摘要： The invention relates to freeze-drying, and more specifically to the production of freeze-dried particles as bulkware. One embodiment of a process line (300) for the production of freeze-dried particles under closed conditions comprises at least the following separate devices: A spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles; and a bulk freeze-dryer (304) for freeze drying the particles; wherein a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304), and for the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for closed operation.
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公开(公告)号：EP2764310B1
公开(公告)日：2016-11-23
申请号：EP12769022.0
申请日：2012-10-04
申请人： Sanofi Pasteur SA
IPC分类号： F26B5/06
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公开(公告)号：EP2764308B1
公开(公告)日：2016-09-14
申请号：EP12769023.8
申请日：2012-10-04
申请人： Sanofi Pasteur SA
CPC分类号： F26B3/30 , F26B5/06 , F26B11/026
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6.发明授权
公开(公告)号：EP3171954B1
公开(公告)日：2018-06-27
申请号：EP15738385.2
申请日：2015-07-20
申请人： Sanofi Pasteur SA
发明人： GEBHARD, Thomas , KAISER, Roland , LUY, Bernhard , PLITZKO, Matthias , STRUSCHKA, Manfred , ZERILLO, Christian
摘要： The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber.
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公开(公告)号：EP2766682A1
公开(公告)日：2014-08-20
申请号：EP12769026.1
申请日：2012-10-04
申请人： Sanofi Pasteur SA
摘要： The invention relates to freeze-drying, and more specifically to the production of freeze-dried particles as bulkware. One embodiment of a process line (300) for the production of freeze-dried particles under closed conditions comprises at least the following separate devices: A spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles; and a bulk freeze-dryer (304) for freeze drying the particles; wherein a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304), and for the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for closed operation.
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公开(公告)号：EP2764311A1
公开(公告)日：2014-08-13
申请号：EP12769025.3
申请日：2012-10-04
申请人： Sanofi Pasteur SA
IPC分类号： F26B5/06
CPC分类号： F26B5/06 , F26B25/00 , F26B25/002
摘要： A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer (100) for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer (100) comprising a rotary drum (104, 302) for receiving the frozen particles, and a stationary vacuum chamber (102) housing the rotary drum (104, 302), wherein for the production of the particles under closed conditions the vacuum chamber (102) is adapted for closed operation during processing of the particles. The drum (104, 302) is in open communication with the vacuum chamber (102) and at least one transfer section (106, 108) is provided for a product transfer between a separate device of the process line and the freeze-dryer (100), the freeze-dryer (100) and the transfer section (106, 108) being separately adapted for closed operation, wherein the transfer section (106, 108) comprises a temperature-controllable inner wall surface
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公开(公告)号：EP2764308A1
公开(公告)日：2014-08-13
申请号：EP12769023.8
申请日：2012-10-04
申请人： Sanofi Pasteur SA
CPC分类号： F26B3/30 , F26B5/06 , F26B11/026
摘要： A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202). The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.
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10.发明授权PROCESS, PROCESS LINE AND USE OF THE PROCESS LINE FOR THE PRODUCTION OF FREEZE-DRIED PARTICLES 有权过程中，工艺路线和生产线的冷冻干燥的颗粒的生产中使用
公开(公告)号：EP2766682B1
公开(公告)日：2016-11-23
申请号：EP12769026.1
申请日：2012-10-04
申请人： Sanofi Pasteur SA
摘要： The invention relates to freeze-drying, and more specifically to the production of freeze-dried particles as bulkware. One embodiment of a process line (300) for the production of freeze-dried particles under closed conditions comprises at least the following separate devices: A spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles; and a bulk freeze-dryer (304) for freeze drying the particles; wherein a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304), and for the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for closed operation.
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