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公开(公告)号：EP2125745A1
公开(公告)日：2009-12-02
申请号：EP07856887.0
申请日：2007-12-19
申请人： Sanofi-Aventis
发明人： PLETTENBURG, Oliver , HOFMEISTER, Armin , LORENZ, Katrin , BRENDEL, Joachim , LÖHN, Matthias , WESTON, John
IPC分类号： C07D217/24 , C07D401/12 , A61K31/472 , A61K31/4725 , A61K31/5377
CPC分类号： C07D217/24 , C07D401/12
摘要： The invention relates to 6-substituted isoquinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹诺酮衍生物和含有这些化合物的组合物。
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公开(公告)号：EP2132194B1
公开(公告)日：2011-03-16
申请号：EP07856891.2
申请日：2007-12-19
申请人： Sanofi-Aventis
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06 , A61K31/4725 , A61P9/00 , A61P3/00 , A61P7/00 , A61P25/00
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
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3.发明公开
公开(公告)号：EP2313374A1
公开(公告)日：2011-04-27
申请号：EP09768948.3
申请日：2009-06-19
申请人： Sanofi-Aventis
IPC分类号： C07D217/24 , C07D217/02 , C07D217/22 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/472 , A61K31/4725 , A61P9/12 , A61P43/00
CPC分类号： C07D417/12 , C07D217/02 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
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4.发明公开
公开(公告)号：EP2303846A1
公开(公告)日：2011-04-06
申请号：EP09768949.1
申请日：2009-06-19
申请人： Sanofi-Aventis
发明人： PLETTENBURG, Oliver , LORENZ, Katrin , WESTON, John , LOEHN, Matthias , KLEEMANN, Heinz-Werner , DUCLOS, Olivier , JEANNOT, Frédéric
IPC分类号： C07D217/24 , A61K31/472 , A61P9/00 , A61P27/00 , A61P25/00 , A61P37/00
CPC分类号： C07D217/24
摘要： The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
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5.发明公开BI-AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINE DERIVATIVES AS RHO KINASE INHIBITORS 有权双环和多环取代的异喹啉和异喹啉衍生物作为Rho激酶抑制剂的
公开(公告)号：EP2303845A2
公开(公告)日：2011-04-06
申请号：EP09768941.8
申请日：2009-06-18
申请人： Sanofi-Aventis
IPC分类号： C07D217/24 , C07D493/08 , C07D495/08 , A61K31/472 , A61P27/00 , A61P9/00 , A61P25/00 , A61P37/00
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R
1 to R
12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.-
6.发明授权CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES 有权CYCLOALKYLAMINSUBSTITUIERTE异喹啉和ISOCHINOLINONDERIVATE
公开(公告)号：EP2102164B1
公开(公告)日：2010-12-01
申请号：EP07856892.0
申请日：2007-12-19
申请人： Sanofi-Aventis
发明人： PLETTENBURG, Oliver , LORENZ, Katrin , GOERLITZER, Jochen , LÖHN, Matthias , BISCARRAT, Sandrine , JEANNOT, Frédéric , DUCLOS, Olivier
IPC分类号： C07D217/24 , A61K31/472 , A61P9/12
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
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公开(公告)号：EP2132194A2
公开(公告)日：2009-12-16
申请号：EP07856891.2
申请日：2007-12-19
申请人： Sanofi-Aventis
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06 , A61K31/4725 , A61P9/00 , A61P3/00 , A61P7/00 , A61P25/00
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
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8.发明公开
公开(公告)号：EP2102164A1
公开(公告)日：2009-09-23
申请号：EP07856892.0
申请日：2007-12-19
申请人： Sanofi-Aventis
发明人： PLETTENBURG, Oliver , LORENZ, Katrin , GOERLITZER, Jochen , LÖHN, Matthias , BISCARRAT, Sandrine , JEANNOT, Frédéric , DUCLOS, Olivier
IPC分类号： C07D217/24 , A61K31/472 , A61P9/12
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与Rho激酶和/或Rho-激酶介导的肌球蛋白轻链磷酸酶磷酸化相关的疾病的式（I）的6-取代的异喹啉和异喹啉酮衍生物，以及含有这种 化合物。
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