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1.发明公开DERIVES DE 7 -ALKYNYL-1.8-NAPHTHYRID0NES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权DERIVES DE 7 -ALKYNYL-1.8-NAPHTHYRID0NES，LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUQUE
公开(公告)号：EP2158201A2
公开(公告)日：2010-03-03
申请号：EP08826268.8
申请日：2008-06-11
申请人： Sanofi-Aventis
发明人： ALAM, Antoine , BISCARRAT, Sandrine , BLANC, Isabelle , BONO, Françoise , DUCLOS, Olivier , MC CORT, Gary
IPC分类号： C07D471/04
CPC分类号： C07D213/73 , C07D213/82 , C07D471/04
摘要： The invention relates to derivatives of 7-alkynyl-1,8-naphthyridones having general formula (I), in which R1, R2, R3 and R4 are as defined in the description. The invention also relates to the preparation method thereof and to the use of same in therapeutics.
摘要翻译： 本发明涉及具有通式（I）的7-炔基-1,8-萘啶酮的衍生物，其中R 1，R 2，R 3和R 4如说明书中所定义。 本发明还涉及其制备方法和其在治疗中的用途。
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2.发明授权DERIVES DE 7-ALKYNYL-1,8-NAPHTHYRIDONES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权DERURES DE 7-炔基-1,8-萘啶酮，LEUR制剂和LEUR应用EN治疗
公开(公告)号：EP2158201B1
公开(公告)日：2011-04-13
申请号：EP08826268.8
申请日：2008-06-11
申请人： Sanofi-Aventis
发明人： ALAM, Antoine , BISCARRAT, Sandrine , BLANC, Isabelle , BONO, Françoise , DUCLOS, Olivier , MC CORT, Gary
IPC分类号： C07D471/04
CPC分类号： C07D213/73 , C07D213/82 , C07D471/04
摘要： The invention relates to derivatives of 7-alkynyl-1,8-naphthyridones having general formula (I), in which R1, R2, R3 and R4 are as defined in the description. The invention also relates to the preparation method thereof and to the use of same in therapeutics.
摘要翻译： 本发明涉及具有通式（I）的7-炔基-1,8-萘啶酮的衍生物，其中R 1，R 2，R 3和R 4如说明书中所定义。 本发明还涉及其制备方法和其在治疗中的用途。
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3.发明公开BI-AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINE DERIVATIVES AS RHO KINASE INHIBITORS 有权双环和多环取代的异喹啉和异喹啉衍生物作为Rho激酶抑制剂的
公开(公告)号：EP2303845A2
公开(公告)日：2011-04-06
申请号：EP09768941.8
申请日：2009-06-18
申请人： Sanofi-Aventis
IPC分类号： C07D217/24 , C07D493/08 , C07D495/08 , A61K31/472 , A61P27/00 , A61P9/00 , A61P25/00 , A61P37/00
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R
1 to R
12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.-
4.发明授权CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES 有权CYCLOALKYLAMINSUBSTITUIERTE异喹啉和ISOCHINOLINONDERIVATE
公开(公告)号：EP2102164B1
公开(公告)日：2010-12-01
申请号：EP07856892.0
申请日：2007-12-19
申请人： Sanofi-Aventis
发明人： PLETTENBURG, Oliver , LORENZ, Katrin , GOERLITZER, Jochen , LÖHN, Matthias , BISCARRAT, Sandrine , JEANNOT, Frédéric , DUCLOS, Olivier
IPC分类号： C07D217/24 , A61K31/472 , A61P9/12
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
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5.发明公开
公开(公告)号：EP2102164A1
公开(公告)日：2009-09-23
申请号：EP07856892.0
申请日：2007-12-19
申请人： Sanofi-Aventis
发明人： PLETTENBURG, Oliver , LORENZ, Katrin , GOERLITZER, Jochen , LÖHN, Matthias , BISCARRAT, Sandrine , JEANNOT, Frédéric , DUCLOS, Olivier
IPC分类号： C07D217/24 , A61K31/472 , A61P9/12
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与Rho激酶和/或Rho-激酶介导的肌球蛋白轻链磷酸酶磷酸化相关的疾病的式（I）的6-取代的异喹啉和异喹啉酮衍生物，以及含有这种 化合物。
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