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1.发明授权NEUE INSULINDERIVATE MIT EXTREM VERZÖGERTEM ZEIT- / WIRKUNGSPROFIL 有权NEUE INSULINDERIVATE MIT EXTREMVERZÖGERTEMZEIT- / WIRKUNGSPROFIL
公开(公告)号：EP2229407B1
公开(公告)日：2016-11-16
申请号：EP09701358.5
申请日：2009-01-06
发明人： HABERMANN, Paul , SEIPKE, Gerhard , KURRLE, Roland , MÜLLER, Günter , SOMMERFELD, Mark , TENNAGELS, Norbert , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07K14/62
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2.发明公开NEUE INSULINDERIVATE MIT EXTREM VERZÖGERTEM ZEIT- / WIRKUNGSPROFIL 有权NEUE INSULINDERIVATE MIT EXTREMVERZÖGERTEMZEIT- / WIRKUNGSPROFIL
公开(公告)号：EP2229406A2
公开(公告)日：2010-09-22
申请号：EP09700949.2
申请日：2009-01-06
发明人： HABERMANN, Paul , SEIPKE, Gerhard , KURRLE, Roland , MÜLLER, Günter , SOMMERFELD, Mark , TENNAGELS, Norbert , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07K14/62
CPC分类号： C07K14/62
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
摘要翻译： 本发明涉及具有基础时间 - 作用谱的新型胰岛素类似物，其特征在于加入和/或置换带负电和带正电荷的氨基酸残基和通过B链和组氨酸的C端羧基的酰胺化 在胰岛素A链的8位。 本发明还涉及其生产和使用。
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3.发明授权
公开(公告)号：EP2229406B1
公开(公告)日：2015-04-22
申请号：EP09700949.2
申请日：2009-01-06
发明人： HABERMANN, Paul , SEIPKE, Gerhard , KURRLE, Roland , MÜLLER, Günter , SOMMERFELD, Mark , TENNAGELS, Norbert , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07K14/62
CPC分类号： C07K14/62
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4.发明公开
公开(公告)号：EP2229407A2
公开(公告)日：2010-09-22
申请号：EP09701358.5
申请日：2009-01-06
发明人： HABERMANN, Paul , SEIPKE, Gerhard , KURRLE, Roland , MÜLLER, Günter , SOMMERFELD, Mark , TENNAGELS, Norbert , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07K14/62
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
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