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1.发明授权
公开(公告)号：EP2229406B1
公开(公告)日：2015-04-22
申请号：EP09700949.2
申请日：2009-01-06
发明人： HABERMANN, Paul , SEIPKE, Gerhard , KURRLE, Roland , MÜLLER, Günter , SOMMERFELD, Mark , TENNAGELS, Norbert , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07K14/62
CPC分类号： C07K14/62
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2.发明授权HYDROXYBIPHENYL-CARBONSÄUREN UND DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权羟基联苯碳酸及其衍生物，用于生产及其用途
公开(公告)号：EP1828107B1
公开(公告)日：2011-09-28
申请号：EP05817600.9
申请日：2005-12-02
IPC分类号： C07C233/87 , C07C233/63 , C07C233/47 , C07C233/51 , C07C235/52 , C07D317/68 , C07D307/68 , A61K31/195 , A61K31/36 , A61K31/341 , A61P3/10
CPC分类号： C07C233/51 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C2601/02 , C07C2601/14 , C07D307/68 , C07D317/68
摘要： The invention relates to substituted hydroxybiphenyls, the derivatives and the physiologically acceptable salts thereof. The invention relates to the compounds of formula (I), wherein the substituents R1, R2 and A are defined as indicated, and to the physiologically acceptable salts thereof. The inventive compounds are suitable e.g. as hypoglycemic drugs and as drugs for use in the prevention and treatment of diabetes.
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3.发明授权NEUE INSULINDERIVATE MIT EXTREM VERZÖGERTEM ZEIT- / WIRKUNGSPROFIL 有权NEUE INSULINDERIVATE MIT EXTREMVERZÖGERTEMZEIT- / WIRKUNGSPROFIL
公开(公告)号：EP2229407B1
公开(公告)日：2016-11-16
申请号：EP09701358.5
申请日：2009-01-06
发明人： HABERMANN, Paul , SEIPKE, Gerhard , KURRLE, Roland , MÜLLER, Günter , SOMMERFELD, Mark , TENNAGELS, Norbert , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07K14/62
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4.发明授权Substituierte 3-Phenyl-5-alkoxy-1,3,4-oxadiazol-2-one sowie ihre Herstellung und Verwendung in Arzneistoffen 有权取代的3-苯基-5-烷氧基-1,3,4-恶二唑-2-酮以及它们的制备和在药物中使用
公开(公告)号：EP1480960B1
公开(公告)日：2012-05-09
申请号：EP03742936.2
申请日：2003-02-14
IPC分类号： C07D271/113 , A61K31/4245 , A61P3/04
CPC分类号： C07D271/113
摘要： The invention relates to substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, of general formula (I), wherein R1 represents C7-C22 alkyl, C2-C4 alkyl that is substituted by C4-C20 alkoxy, C6-C10 aryl, C6-C10 aryloxy or C4-C12-alkoxy-C2-C4-alkoxy, and represents C7-C20 alkenyl, 3β-cholestan-3-yl or substituted phenyl; R2, R3, R4 and R5 represent hydrogen, halogen, nitro, C1-C4 alkyl, C1-C9 alkyloxy, trifluoromethyl, trifluoromethoxy or C6-C10-aryl-C1-C4-alkyloxy, C6-C10 aryloxy, C6-C10 aryl, C3-C8 cycloalkyl or O-C3-C8-cycloalkyl, whereby all of these can be substituted. The invention also relates to methods for producing these compounds. The compounds of formula (I) have an inhibiting effect on the pancreatic lipase and can be used as active substances for treating obesity.
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5.发明公开HYDROXYBIPHENYL-CARBONSÄUREN UND DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权羟基苯乙烯碳氢化合物，VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG
公开(公告)号：EP1828107A1
公开(公告)日：2007-09-05
申请号：EP05817600.9
申请日：2005-12-02
IPC分类号： C07C233/87 , C07C233/63 , C07C233/47 , C07C233/51 , C07C235/52 , C07D317/68 , C07D307/68 , A61K31/195 , A61K31/36 , A61K31/341 , A61P3/10
CPC分类号： C07C233/51 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C2601/02 , C07C2601/14 , C07D307/68 , C07D317/68
摘要： The invention relates to substituted hydroxybiphenyls, the derivatives and the physiologically acceptable salts thereof. The invention relates to the compounds of formula (I), wherein the substituents R1, R2 and A are defined as indicated, and to the physiologically acceptable salts thereof. The inventive compounds are suitable e.g. as hypoglycemic drugs and as drugs for use in the prevention and treatment of diabetes.
摘要翻译： 公开了本文定义的式I的新化合物及其作为用于降低血糖的药物活性化合物和/或治疗II型糖尿病，脂质和碳水化合物代谢紊乱，动脉硬化表现和胰岛素抵抗的一种或多种的用途。
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公开(公告)号：EP1713779A1
公开(公告)日：2006-10-25
申请号：EP05700954.0
申请日：2005-01-15
IPC分类号： C07D231/56 , A61K31/416 , A61P3/10
CPC分类号： C07D413/12 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The invention relates to indazole derivatives of general formula (I) or (II), with the meanings as given in the description, the pharmaceutically-acceptable salts and use thereof as medicaments.
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7.发明公开
公开(公告)号：EP2229407A2
公开(公告)日：2010-09-22
申请号：EP09701358.5
申请日：2009-01-06
发明人： HABERMANN, Paul , SEIPKE, Gerhard , KURRLE, Roland , MÜLLER, Günter , SOMMERFELD, Mark , TENNAGELS, Norbert , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07K14/62
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
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公开(公告)号：EP1713779B1
公开(公告)日：2011-04-13
申请号：EP05700954.0
申请日：2005-01-15
IPC分类号： C07D231/56 , A61K31/416 , A61P3/10
CPC分类号： C07D413/12 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The invention relates to indazole derivatives of general formula (I) or (II), with the meanings as given in the description, the pharmaceutically-acceptable salts and use thereof as medicaments.
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9.发明授权HEFESTAMM VON SACCHAROMYCES CEREVISIAE MIT FUNKTIONELLER EXPRESSION EINES GLUT-TRANSPORTERS 有权含有A GLUT转运体功能性表达酿酒酵母的酵母菌株
公开(公告)号：EP1373506B1
公开(公告)日：2009-04-15
申请号：EP02719792.0
申请日：2002-02-09
摘要： The invention relates to a yeast strain of Saccharomyces cerevisiae which, due to deletion of the genomic sequences, does not produce any hexose transporters and which as a consequence cannot propagate on substrates that have hexose as the only carbon source. The capability of the strain of propagating on substrates that have hexose as the only carbon source can be re-established by expression of a GLUT4 gene.
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10.发明公开NEUE INSULINDERIVATE MIT EXTREM VERZÖGERTEM ZEIT- / WIRKUNGSPROFIL 有权NEUE INSULINDERIVATE MIT EXTREMVERZÖGERTEMZEIT- / WIRKUNGSPROFIL
公开(公告)号：EP2229406A2
公开(公告)日：2010-09-22
申请号：EP09700949.2
申请日：2009-01-06
发明人： HABERMANN, Paul , SEIPKE, Gerhard , KURRLE, Roland , MÜLLER, Günter , SOMMERFELD, Mark , TENNAGELS, Norbert , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07K14/62
CPC分类号： C07K14/62
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
摘要翻译： 本发明涉及具有基础时间 - 作用谱的新型胰岛素类似物，其特征在于加入和/或置换带负电和带正电荷的氨基酸残基和通过B链和组氨酸的C端羧基的酰胺化 在胰岛素A链的8位。 本发明还涉及其生产和使用。
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