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公开(公告)号：EP1628972B1
公开(公告)日：2009-04-22
申请号：EP04731155.0
申请日：2004-05-05
发明人： NAZARE, Marc , WEHNER, Volkmar , LAUX, Volker , URMANN, Matthias , BAUER, Armin , MATTER, Hans
IPC分类号： C07D413/14 , C07D401/14 , C07D401/12 , C07D413/04 , A61K31/416 , A61P7/02
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14
摘要： The present invention relates to compounds of the formulae (I) and (Ib) wherein R0; R1 ;R2 ;Q; V, G and M have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formulae (I) and (Ib), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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公开(公告)号：EP1628971A1
公开(公告)日：2006-03-01
申请号：EP04731152.7
申请日：2004-05-05
发明人： NAZARE, Marc , LAUX, Volker , BAUER, Armin , WAGNER, Michael
IPC分类号： C07D413/14 , A61K31/4196 , A61P7/02
CPC分类号： C07D413/14
摘要： The present invention relates to compounds of the formulae (I) and (II), in which RO; R1; R3; Q; J1; J2; J3; J4; J5; V; G and M have the meanings indicated in the claims. The compounds of the formulae (I) and (II) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formulae (I) and (II), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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公开(公告)号：EP1628971B1
公开(公告)日：2008-05-07
申请号：EP04731152.7
申请日：2004-05-05
发明人： NAZARE, Marc , LAUX, Volker , BAUER, Armin , WAGNER, Michael
IPC分类号： C07D413/14 , A61K31/4196 , A61P7/02
CPC分类号： C07D413/14
摘要： The present invention relates to compounds of the formulae (I) and (II), in which RO; R1; R3; Q; J1; J2; J3; J4; J5; V; G and M have the meanings indicated in the claims. The compounds of the formulae (I) and (II) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formulae (I) and (II), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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公开(公告)号：EP1633746B1
公开(公告)日：2010-07-28
申请号：EP04731170.9
申请日：2004-05-05
发明人： NAZARE, Marc , WEHNER, Volkmar , RITTER, Kurt , LAUX, Volker
IPC分类号： C07D413/14 , C07D401/14 , A61K31/404 , A61P7/02
CPC分类号： C07D413/14
摘要： The present invention relates to compounds of the formula (I) in which R0 ; R1 ; R2 ; R3 ; R4 ; R5 ; R6 ; R7 ; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor Vila (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor Vila is present or for the cure or prevention of which an inhibition of factor Xa and/or factor Vila is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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公开(公告)号：EP1633746A1
公开(公告)日：2006-03-15
申请号：EP04731170.9
申请日：2004-05-05
发明人： NAZARE, Marc , WEHNER, Volkmar , RITTER, Kurt , LAUX, Volker
IPC分类号： C07D413/14
CPC分类号： C07D413/14
摘要： The present invention relates to compounds of the formula (I) in which R0 ; R1 ; R2 ; R3 ; R4 ; R5 ; R6 ; R7 ; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor Vila (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor Vila is present or for the cure or prevention of which an inhibition of factor Xa and/or factor Vila is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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公开(公告)号：EP1628972A1
公开(公告)日：2006-03-01
申请号：EP04731155.0
申请日：2004-05-05
发明人： NAZARE, Marc , WEHNER, Volkmar , LAUX, Volker , URMANN, Matthias , BAUER, Armin , MATTER, Hans
IPC分类号： C07D413/14 , C07D401/14 , C07D401/12 , C07D413/04 , A61K31/416 , A61P7/02
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14
摘要： The present invention relates to compounds of the formulae (I) and (Ib) wherein R0; R1 ;R2 ;Q; V, G and M have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formulae (I) and (Ib), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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