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1.
公开(公告)号:EP1611083B1
公开(公告)日:2007-10-03
申请号:EP04719953.4
申请日:2004-03-12
IPC分类号: C07C69/94 , C07D263/32
CPC分类号: C07D263/32 , C07C67/307 , C07C69/76
摘要: The invention relates to a method for producing compounds of formula (I) wherein R represents H, optionally halogen-substituted alkyl, cycloalkyl or aryl, alkyl-aryl or heteroaryl, and at least one CH2 group can be replaced by O in alkyl and cycloalkyl. Said compounds of formula (I) are valuable intermediates in the synthesis of PPAR agonists.
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公开(公告)号:EP1786913B1
公开(公告)日:2011-08-17
申请号:EP05782434.4
申请日:2005-08-23
发明人: SALAGNAD, Christophe , ZOCHER, Frank , BURGARD, Andreas , JUNKER, Bernd , HOERLEIN, Rolf , STUEDEMANN, Thomas , MAIER, Claus-Jürgen , HACHTEL, Jochen , HOLLA, Wolfgang , TAPPERTZHOFEN, Christoph , KULITZSCHER, Berndt , MUTTI, Stéphane
IPC分类号: C12P7/62
CPC分类号: C07D413/12 , C07D263/62 , C07D309/12 , C12P17/14 , Y02P20/55
摘要: The invention relates to a method for producing diarylcycloalkyl derivatives of general formula (I), wherein the radicals have the indicated meanings. The invention further relates to novel intermediate products that are formed by means of the inventive method, methods for producing intermediate products of compounds of general formula (I), and a method for separating cis/trans isomer mixtures from starting materials used for the production of compounds of general formula (I).
摘要翻译: 本发明涉及用于生产通式(I)的二芳基环烷基衍生物的方法,其中基团具有所指出的含义。 本发明进一步涉及通过本发明方法形成的新颖中间产物,用于制备通式(I)化合物的中间产物的方法,以及从用于生产通式(I)化合物的原料中分离顺式/反式异构体混合物的方法 通式(I)的化合物。
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3.
公开(公告)号:EP1786913A2
公开(公告)日:2007-05-23
申请号:EP05782434.4
申请日:2005-08-23
发明人: SALAGNAD, Christophe , ZOCHER, Frank , BURGARD, Andreas , JUNKER, Bernd , HOERLEIN, Rolf , STUEDEMANN, Thomas , MAIER, Claus-Jürgen , HACHTEL, Jochen , HOLLA, Wolfgang , TAPPERTZHOFEN, Christoph , KULITZSCHER, Berndt , MUTTI, Stéphane
IPC分类号: C12P7/62
CPC分类号: C07D413/12 , C07D263/62 , C07D309/12 , C12P17/14 , Y02P20/55
摘要: The invention relates to a method for producing diarylcycloalkyl derivatives of general formula (I), wherein the radicals have the indicated meanings. The invention further relates to novel intermediate products that are formed by means of the inventive method, methods for producing intermediate products of compounds of general formula (I), and a method for separating cis/trans isomer mixtures from starting materials used for the production of compounds of general formula (I).
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公开(公告)号:EP1611083A1
公开(公告)日:2006-01-04
申请号:EP04719953.4
申请日:2004-03-12
IPC分类号: C07C69/94 , C07D263/32
CPC分类号: C07D263/32 , C07C67/307 , C07C69/76
摘要: The invention relates to a method for producing compounds of formula (I) wherein R represents H, optionally halogen-substituted alkyl, cycloalkyl or aryl, alkyl-aryl or heteroaryl, and at least one CH2 group can be replaced by O in alkyl and cycloalkyl. Said compounds of formula (I) are valuable intermediates in the synthesis of PPAR agonists.
摘要翻译: 本发明涉及制备式(I)化合物的方法,其中R表示H,任选卤素取代的烷基,环烷基或芳基,烷基 - 芳基或杂芳基,并且至少一个CH 2基团可以在烷基和环烷基中被O替代 。 所述式(I)化合物是合成PPAR激动剂的有价值的中间体。
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