公开(公告)号：EP0950048A1

公开(公告)日：1999-10-20

申请号：EP97951323.0

申请日：1997-12-12

申请人： Sanofi-Synthélabo

发明人： BARONI, Marco ,  CARDAMONE, Rosanna ,  FOURNIER, Jacqueline ,  GUZZI, Umberto

IPC分类号： A61K31 ,  A61P25 ,  C07D211 ,  C07D401 ,  C07D213

CPC分类号： C07D401/04 ,  C07D211/70

摘要： The invention concerns compounds of formula (I) in which Y represents -CH- or -N-; R1 represents hydrogen, a halogen, a CF3 group, (C1-C4)alkyl or (C1-C4)alcoxyl; R2 represents a methyl or ethyl group; R3 and R4 each represent hydrogen or a (C1-C3)alkyl; X represents (a) a (C1-C6)alkyl; a (C1-C6)alcoxyl; a (C3-C7)carboxyalkyl; a (C1-C4)alcoxycarbonyl(C1-C6)alkyl; a (C3-C7)carboxyalcoxyl; or a (C1-C4)alcoxycarbonyl(C1-C6)alcoxyl; (b) a radical selected among a (C3-C7)cycloalkyl, (C3-C7)cycloalkyloxy, (C3-C7)cycloalkylmethyl, (C3-C7)cycloalkylamino and cyclohexenyl, said radical can be substituted by a halogen, hydroxy, (C1-C4)alcoxy, carboxy, (C1-C4)alcoxycarbonyl, amino, mono- or di-(C1-C4) alkylamino; or (c) a group selected among a phenyl, phenoxy, phenylamino, N-(C1-C3)alkylphenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsuphonyl, phenylsulphinyl or styryl, said group can be mono- or poly-substituted by a halogen, CF3, (C1-C4)alkyl, (C1-C4)alcoxy, cyano, amino, mono- or di-(C1-C4)alkylamino, (C1-C4)acylamino, carboxy, (C1-C4)alcoxycarbonyl, aminocarbonyl, mono- or di-(C1-C4)alkylaminocarbonyl, amino(C1-C4)alkyl, hydroxy(C1-C4)alkyl or halogeno(C1-C4)alkyl. The invention also concerns a method for preparing them and the pharmaceutical compositions containing them. These compounds have a neurotrophic and neuroprotecting activity.

公开(公告)号：EP0950049A1

公开(公告)日：1999-10-20

申请号：EP97951326.0

申请日：1997-12-12

申请人： Sanofi-Synthélabo

发明人： BARONI, Marco ,  CARDAMONE, Rosanna ,  FOURNIER, Jacqueline ,  GUZZI, Umberto

IPC分类号： A61K31 ,  A61P25 ,  C07D211 ,  C07D277 ,  C07D401 ,  C07D213

CPC分类号： C07D401/04 ,  C07D211/70

摘要： The invention relates to the compounds of formula: (I) wherein Y represents -CH- or -N-; R1 represents a halogen, a CF3 group, (C1-C4) alkyl or (C1-C4) oxyalkylate; R2 and R3 each represent hydrogen or a (C1-C3) alkyl; n represents 0 or 1 Ph1 and Ph2 each independently represent a non-substituted, monosubstituted, or polysubstituted phenyl group. The invention further concerns a process for the preparation of the compounds as well as the pharmaceutical compositions which contain them. These compounds have neurotrophic and neuro-protective properties.