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公开(公告)号：EP3330710B1
公开(公告)日：2020-09-09
申请号：EP16832913.4
申请日：2016-07-28
发明人： HONMOU Osamu , WANIBUCHI Masahiko , OHTAKI Shunya , SASAKI Masanori , SASAKI Yuko , MIKUNI Nobuhiro
IPC分类号： G01N33/574 , C12Q1/6886 , A61K39/395 , A61K48/00 , C07K16/30 , A61P35/00
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公开(公告)号：EP3330710A1
公开(公告)日：2018-06-06
申请号：EP16832913.4
申请日：2016-07-28
发明人： HONMOU Osamu , WANIBUCHI Masahiko , OHTAKI Shunya , SASAKI Masanori , SASAKI Yuko , MIKUNI Nobuhiro
CPC分类号： G01N33/57407 , A61P35/00 , C07K16/3053 , C07K2317/76 , C12N15/09 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N2333/4712 , G01N2800/52
摘要： [Problem]
The present invention addresses the problem of providing a novel biomarker which makes it possible to find the prognosis of a glioma, the risk of distant recurrence of a glioma, the invasion ability of glioma cells and the like and also makes it possible to detect the prognosis, the risk, the invasion ability or the like in an earlier stage of a therapy of glioma.
[Solution]
The present invention relates to a method for evaluating the prognosis of a glioma, said method comprising the steps of: detecting ACTC1 protein and/or mRNA encoding the protein in a glioma-containing sample collected from a patient; and determining that the prognosis of the glioma is poor when the ACTC1 protein and/or the mRNA encoding the protein is detected in the aforementioned step. According to the present invention, the prognosis of a glioma, the risk of distant recurrence of a glioma, the invasion ability and the like can be evaluated using a novel biomarker, i.e., ACTC1 protein and/or mRNA encoding the protein.
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