公开(公告)号：EP2193807A1

公开(公告)日：2010-06-09

申请号：EP08828474.0

申请日：2008-08-22

申请人： Sapporo Medical University ,  Tokyo University of Science ,  Kyoto University ,  Sapporo Immuno Diagnostic Laboratory

发明人： SAHARA, Hiroeki ,  MORI, Yoko ,  TAKAHASHI, Nobuaki ,  SATO, Noriyuki ,  SUGAWARA, Fumio ,  SAKAGUCHI, Kengo ,  MOROHASHI, Kengo ,  IWABATA, Kazuki ,  WATASHI, Koichi ,  SHIMOTOHNO, Kunitada ,  KIKUCHI, Kokichi ,  TSUTAE, Wataru ,  MIYASHITA, Hiroki

IPC分类号： A61K45/00 ,  C12N5/10 ,  C12N15/09

CPC分类号： C07K14/47 ,  G01N33/5767 ,  Y02A50/53 ,  Y02A50/60

摘要： Abstract: Disclosed are: a composition and a method for the diagnosis and/or the treatment of a CSABP-related disease, the regulation of the proliferation of an RNA virus and the regulation of an RNA-metabolizing system, which targets a cyclosporine A-binding protein (CSABP); a method for the screening of a component that targets a CSABP; a composition and a method for the detection/inhibition of CsA, NS5B or cyclosphilin B by utilizing a CSABP; a promoter for a CSABP; a method for the screening of a substance capable of regulating the expression of a CSABP by utilizing the promoter; and a method for the determination of the occurrence or clinical stage of a CSABP-related disease.

摘要翻译： 摘要：公开了一种用于诊断和/或治疗CSABP相关疾病的组合物和方法，RNA病毒增殖的调节和RNA代谢系统的调节，其靶向环孢菌素A- 结合蛋白（CSABP）; 用于筛选针对CSABP的组件的方法; 通过利用CSABP检测/抑制CsA，NS5B或环孢菌素B的组合物和方法; CSABP的启动子; 通过利用该启动子筛选能够调节CSABP表达的物质的方法; 以及用于确定CSABP相关疾病的发生或临床阶段的方法。