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    TRIPHASIC DOSING REGIMENS FOR THE ADMINISTRATION OF TIME-DEPENDENT ANTIBIOTICS AND DEVICES FOR THE SAME
    1.
    发明公开
    TRIPHASIC DOSING REGIMENS FOR THE ADMINISTRATION OF TIME-DEPENDENT ANTIBIOTICS AND DEVICES FOR THE SAME 审中-公开
    用于管理时间依赖性抗生素和相同装置的三元给药方案

    公开(公告)号：EP3233063A2

    公开(公告)日：2017-10-25

    申请号：EP15870990.7

    申请日：2015-12-16

    申请人： ScPharmaceuticals Inc.

    发明人： MUNTENDAM, Pieter

    IPC分类号： A61K9/22 ,  A61K31/43

    CPC分类号： A61K31/546 ,  A61K9/0019 ,  A61K9/0097

    摘要： Methods for the treatment of infections and other diseases or conditions with a biphasic or triphasic dosing regimen of a time-dependent antibiotic are provided, where the total time of administration can occur over a period of less than 24 hours. The present teachings also provide a micropump or patch pump device which permits controlled, subcutaneous infusion of a time-dependent antibiotic according to the dosing regimens of the present teachings.

    摘要翻译： 提供了用时间依赖性抗生素的双相或三相给药方案治疗感染和其他疾病或病症的方法，其中总给药时间可以在不到24小时的时间内发生。 本教导还提供了微泵或贴片泵装置，其允许根据本教导的给药方案受控地皮下注射时间依赖性抗生素。

    PHARMACEUTICAL FORMULATIONS FOR SUBCUTANEOUS ADMINISTRATION OF FUROSEMIDE
    3.
    发明公开
    PHARMACEUTICAL FORMULATIONS FOR SUBCUTANEOUS ADMINISTRATION OF FUROSEMIDE 审中-公开
    药物制剂呋皮下注射

    公开(公告)号：EP2981258A1

    公开(公告)日：2016-02-10

    申请号：EP14778339.3

    申请日：2014-04-03

    申请人： ScPharmaceuticals Inc.

    发明人： MICHAELS, Scott, A. ,  MUNTENDAM, Pieter ,  LARSEN, Glenn, R.

    IPC分类号： A61K31/341

    摘要： The present teachings relate to liquid pharmaceutical formulations of furosemide, where the pharmaceutical formulations include a molar excess of tris(hydroxymethyl)aminomethane to furosemide, have a pH in the range of 7 to 8.5, and a concentration of tris(hydroxymethyl)aminomethane greater than or equal to about 50 mM. The present teachings can improve the stability of liquid pharmaceutical formulations including furosemide and the suitability of such pharmaceutical formulations for subcutaneous administration or delivery.