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1.发明公开KONJUGATE MAKROCYCLISCHER METALLKOMPLEXE MIT BIOMOLEKÜLEN UND DEREN VERWENDUNG ZUR HERSTELLUNG VON MITTELN FÜR NMR- UND RADIODIAGNOSTIK SOWIE DIE RADIOTHERAPIE 审中-公开缀合物与生物分子的大环金属配合物和它们在核磁共振和无线电诊断资金的生产与放射治疗
公开(公告)号：EP1450864A2
公开(公告)日：2004-09-01
申请号：EP02794507.0
申请日：2002-07-18
申请人： Schering AG
发明人： PLATZEK, Johannes , SCHMITT-WILLICH, Heribert , MICHL, Günther , FRENZEL, Thomas , SÜLZLE, Detlev , BAUER, Hans , RADÜCHEL, Bernd , WEINMANN, Hanns-Joachim , SCHIRMER, Heiko
CPC分类号： A61K49/14 , A61K49/0002 , A61K49/085 , A61K49/143
摘要： The invention relates to conjugates comprised of macrocyclic metal complexes with biomolecules and to the production thereof. The conjugates are suited for use as contrast agents in NMR diagnosis and radiodiagnosis and as agents for radiotherapy. A high relaxivity is achieved and a fine tuning of the relaxivity is made possible by a special liganding of the macrocycles.
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2.发明公开MAKROCYCLISCHE METALLKOMPLEXE UND DEREN VERWENDUNG ZUR HERSTELLUNG VON KONJUGATEN MIT BIOMOLEKÜLEN 有权大环金属配合物和它们在偶联物与生物分子生产
公开(公告)号：EP1409024A1
公开(公告)日：2004-04-21
申请号：EP02754904.7
申请日：2002-07-18
申请人： Schering AG
发明人： PLATZEK, Johannes , SCHMITT-WILLICH, Heribert , MICHL, Günther , FRENZEL, Thomas , SÜLZLE, Detlev , BAUER, Hans , RADÜCHEL, Bernd , WEINMANN, Hanns-Joachim , SCHIRMER, Heiko
IPC分类号： A61K47/48 , A61K49/00 , C07D257/02 , C07F5/00
CPC分类号： A61K49/10 , A61K47/54 , A61K47/547 , A61K49/0002 , A61K49/085 , A61K49/14 , A61K49/143 , C07D257/02
摘要： The invention relates to macrocyclic metal complexes and production and use thereof for production of conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR and radio diagnostics and for radiotherapy. According to the invention, a high relaxivity and a fine-tuning of the relaxivity may be achieved by means of a special ligand formation with the macrocycles.
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