公开(公告)号：EP2417135A1

公开(公告)日：2012-02-15

申请号：EP10714399.2

申请日：2010-04-05

申请人： Schering Corporation

发明人： HO, Ginny, D. ,  SMITH, Elizabeth, M. ,  KISELGOF, Eugenia, Y. ,  BASU, Kallol ,  TAN, Zheng ,  MCKITTRICK, Brian ,  TULSHIAN, Deen

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P3/04 ,  A61P3/10 ,  A61P25/00

CPC分类号： C07D471/04

摘要： The present invention relates to substituted triazolopyridines and analogs thereof, the use of the compounds as phosphodiesterase 10 (PDE10) inhibitors for the treatment of PDE10-modulated disorders, to pharmaceutical compositions comprising the compounds.

公开(公告)号：EP2350072A1

公开(公告)日：2011-08-03

申请号：EP09748190.7

申请日：2009-10-26

申请人： Schering Corporation

发明人： HO, Ginny D ,  YANG, Shu-Wei ,  SMITH, Elizabeth M ,  MCELROY, William Thomas ,  BASU, Kallol ,  SMOTRYSKI, Jennifer ,  TAN, Zheng ,  MCKITTRICK, Brian A. ,  TULSHIAN, Deen B.

IPC分类号： C07D471/04 ,  C07D491/113 ,  A61K31/4439 ,  A61P25/18

CPC分类号： C07D471/04 ,  C07D491/113

摘要： The present invention relates to substituted pyrazoloquinolines of formula I and derivatives thereof, the use of the compounds as phosphodiesterase 10 (PDElO) inhibitors for the treatment of PDElO -modulated disorders, to pharmaceutical compositions comprising the compounds, and to the use of additional substituted pyrazoloquinolines and derivatives thereof for the treatment of PDElO -modulated disorders.