公开(公告)号：EP2215064A1

公开(公告)日：2010-08-11

申请号：EP08847176.8

申请日：2008-10-16

申请人： Schering Corporation

发明人： SIDDIQUI, Arshad, M. ,  DAI, Chaoyang ,  MANSOOR, Umar Faruk ,  YANG, Liping ,  VITHARANA, Lalalnthi, Dilrukshi ,  ANGELES, Angie R. ,  SHIPPS, Gerald W., Jr. ,  HUANG, Xiaohua ,  CHENG, Cliff

IPC分类号： C07D231/54 ,  C07D471/00 ,  C07D493/00 ,  A61K31/415 ,  A61P35/00

CPC分类号： C07D231/54 ,  C07D471/00 ,  C07D493/00

摘要： The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, R27, R28, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity.

摘要翻译： 本发明涉及下式（I）的化合物（其中X，R 1，R 2，R 3，R 27，R 28，p，E，环A和环B如本文所定义）。 本发明还涉及包含这些化合物的组合物（包括药学上可接受的组合物），其单独地并且与一种或多种另外的治疗剂组合，并且涉及它们用于抑制KSP驱动蛋白活性并用于治疗与其相关的细胞增殖性疾病或病症的方法 与KSP驱动蛋白活动。