公开(公告)号：EP2430027A1

公开(公告)日：2012-03-21

申请号：EP10722996.5

申请日：2010-05-17

申请人： Roquette Freres

发明人： FUERTES, Patrick ,  IBERT, Mathias ,  FLEURY, Etienne ,  BERNARD, Julien ,  DROCKENMULLER, Eric ,  BESSET, Céline

IPC分类号： C07D493/00 ,  C07D493/04 ,  C07D519/00 ,  C08G73/00

CPC分类号： C07D493/00 ,  C07D493/04 ,  C07D519/00 ,  C08G73/0605 ,  C08G73/08 ,  C09D179/06

摘要： The present invention relates to novel oligomers and polymers and the various methods of obtaining them from monomers derived from 1,4:3,6-dianhydrohexitol, to the method of preparing these monomers, and to novel intermediate dimer compounds and to the preparation method thereof. The present invention also targets the applications of these polymer materials to the formation by extrusion, extrusion-blow moulding, or injection moulding or compression moulding, and to the coating of supports.

公开(公告)号：EP2430027B1

公开(公告)日：2016-02-10

申请号：EP10722996.5

申请日：2010-05-17

申请人： Roquette Frères

发明人： FUERTES, Patrick ,  IBERT, Mathias ,  FLEURY, Etienne ,  BERNARD, Julien ,  DROCKENMULLER, Eric ,  BESSET, Céline

IPC分类号： C07D493/00 ,  C07D493/04 ,  C07D519/00 ,  C08G73/00 ,  C09D179/06

CPC分类号： C07D493/00 ,  C07D493/04 ,  C07D519/00 ,  C08G73/0605 ,  C08G73/08 ,  C09D179/06

公开(公告)号：EP2215064A1

公开(公告)日：2010-08-11

申请号：EP08847176.8

申请日：2008-10-16

申请人： Schering Corporation

发明人： SIDDIQUI, Arshad, M. ,  DAI, Chaoyang ,  MANSOOR, Umar Faruk ,  YANG, Liping ,  VITHARANA, Lalalnthi, Dilrukshi ,  ANGELES, Angie R. ,  SHIPPS, Gerald W., Jr. ,  HUANG, Xiaohua ,  CHENG, Cliff

IPC分类号： C07D231/54 ,  C07D471/00 ,  C07D493/00 ,  A61K31/415 ,  A61P35/00

CPC分类号： C07D231/54 ,  C07D471/00 ,  C07D493/00

摘要： The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, R27, R28, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity.

摘要翻译： 本发明涉及下式（I）的化合物（其中X，R 1，R 2，R 3，R 27，R 28，p，E，环A和环B如本文所定义）。 本发明还涉及包含这些化合物的组合物（包括药学上可接受的组合物），其单独地并且与一种或多种另外的治疗剂组合，并且涉及它们用于抑制KSP驱动蛋白活性并用于治疗与其相关的细胞增殖性疾病或病症的方法 与KSP驱动蛋白活动。

公开(公告)号：EP4375281A1

公开(公告)日：2024-05-29

申请号：EP22845193.6

申请日：2022-07-12

申请人： Medshine Discovery Inc.

发明人： LEI, Maoyi ,  XU, Yu ,  LUO, Yunfu ,  CHEN, Shuhui

IPC分类号： C07D413/04 ,  C07D491/00 ,  C07D405/04 ,  C07D493/00 ,  C07D307/79 ,  C07D401/04 ,  A61K31/421 ,  A61K31/445 ,  A61P35/00

CPC分类号： A61K31/421 ,  A61K31/445 ,  A61P35/00 ,  C07D307/79 ,  C07D405/04 ,  C07D401/04 ,  C07D413/04 ,  C07D491/00 ,  C07D493/00

摘要： A heteroaryl-3-piperidinedione compound and the use thereof. Particularly disclosed are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3353327A1

公开(公告)日：2018-08-01

申请号：EP16847650.5

申请日：2016-09-23

申请人： Agriculture Victoria Services PTY Limited

发明人： SPANGENBERG, German Carlos ,  GUTHRIDGE, Kathryn Michaela ,  MANN, Ross ,  SAWBRIDGE, Timothy Ivor ,  HETTIARACHCHIGE, Inoka Kumari ,  EKANAYAKE, Piyumi Niroshini ,  BROHIER, Natasha Denise ,  ROCHFORT, Simone Jane ,  EDWARDS, Jacqueline

IPC分类号： C12Q1/68 ,  C12N1/14 ,  A01H17/00 ,  A01N63/04 ,  C07D493/00

CPC分类号： A01N63/00 ,  A01H17/00 ,  A01N63/04 ,  C07D493/00 ,  C07D493/08 ,  C12N1/14 ,  C12N1/20 ,  C12N15/1003 ,  C12P5/007 ,  C12P17/06 ,  C12Q1/689 ,  C12Q1/6895 ,  C12Q2600/156 ,  C12R1/01 ,  C12R1/645

摘要： The present invention relates to endophytes, in particular endophytes associated with plants of the Brachiaria-Urochloa species complex, plants infected with the endophytes, products produced by the endophytes, and related methods.

公开(公告)号：EP3186234A1

公开(公告)日：2017-07-05

申请号：EP15763721.6

申请日：2015-08-31

申请人： Iowa State University Research Foundation, Inc. ,  Archer Daniels Midland Co.

发明人： WILLIAMS, Christopher R ,  PODOLSKY, Joseph, Herbert ,  COCHRAN, Eric, W. ,  HAGBERG, Erik

IPC分类号： C07D303/00 ,  C08K5/1515 ,  C08L95/00 ,  D06N5/00

CPC分类号： C08L95/00 ,  C07D493/00 ,  C07D493/04 ,  C08K5/05 ,  C08K5/1515 ,  C08L2555/24 ,  C08L2555/64 ,  D06N5/003 ,  Y02A30/333

摘要： The present invention relates to a method of producing an improved asphalt. The method involves providing an asphalt and providing a compound of formula (I), as described herein. The asphalt is mixed with the compound of formula (I) under conditions effective to produce an improved asphalt. Also disclosed are an asphalt product and a method of making asphalt material. The invention further discloses a method of producing an improved asphalt comprising providing a polymer modified asphalt and providing a compound of formula (IIa) or formula (II). The polymer modified asphalt is mixed with the compound of formula (Ila) or formula (IIb) under conditions effective to produce an improved asphalt, which is yet another aspect of the present invention.

摘要翻译： 本发明涉及一种生产改进沥青的方法。 该方法包括提供沥青并提供如本文所述的式（I）化合物。 沥青在有效生产改进沥青的条件下与式（I）化合物混合。 还公开了沥青产品和制造沥青材料的方法。 本发明进一步公开了生产改良沥青的方法，其包括提供聚合物改性沥青并提供式（IIa）或式（II）化合物。 将聚合物改性沥青与式（IIa）或式（IIb）化合物在有效产生改进沥青的条件下混合，这是本发明的又一方面。