公开(公告)号：EP1318983A2

公开(公告)日：2003-06-18

申请号：EP01973110.8

申请日：2001-09-18

申请人： Schering Corporation

发明人： ASLANIAN, Robert, G. ,  ROSENBLUM, Stuart, B. ,  MUTAHI, Mwangi, Wa ,  SHIH, Neng-Yang ,  PIWINSKI, John, J.

IPC分类号： C07D233/54 ,  C07D401/12 ,  C07D401/14 ,  A61K31/415 ,  A61P25/00

CPC分类号： C07D233/64 ,  C07D401/12 ,  C07D401/14

摘要： The present invention discloses novel substituted imidazole compounds which have either or dual histamine-H1 and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, inflammatory and CNS-related diseases and others.

公开(公告)号：EP1326858A2

公开(公告)日：2003-07-16

申请号：EP01983968.7

申请日：2001-10-15

申请人： Schering Corporation

发明人： ASLANIAN, Robert, G. ,  SHIH, Neng-Yang ,  TING, Pauline, C. ,  BERLIN, Michael, Y. ,  ROSENBLUM, Stuart, B. ,  MC CORMICK, Kevin, D. ,  TOM, Wing, C. ,  BOYCE, Christopher, W. ,  MANGIARACINA, Pietro ,  MUTAHI, Mwangi, Wa ,  PIWINSKI, John, J.

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D401/12 ,  C07D409/14 ,  C07D498/04 ,  C07D417/14

CPC分类号： C07D213/73 ,  A61K31/435 ,  A61K31/445 ,  A61K31/495 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

摘要： Disclosed are novel compounds of the formula: (I) Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I). Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula (I). Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula (I) in combination with a H1 receptor antagonist.

公开(公告)号：EP1318983B1

公开(公告)日：2008-10-22

申请号：EP01973110.8

申请日：2001-09-18

申请人： Schering Corporation

发明人： ASLANIAN, Robert, G. ,  ROSENBLUM, Stuart, B. ,  MUTAHI, Mwangi, Wa ,  SHIH, Neng-Yang ,  PIWINSKI, John, J.

IPC分类号： C07D233/54 ,  C07D401/12 ,  C07D401/14 ,  A61K31/415 ,  A61P25/00

CPC分类号： C07D233/64 ,  C07D401/12 ,  C07D401/14

摘要： The present invention discloses novel substituted imidazole compounds which have either or dual histamine-H1 and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, inflammatory and CNS-related diseases and others.

公开(公告)号：EP1028947B1

公开(公告)日：2002-06-12

申请号：EP98956442.2

申请日：1998-11-05

申请人： SCHERING CORPORATION

发明人： ASLANIAN, Robert, G. ,  McCORMICK, Kevin, D. ,  MUTAHI, Mwangi, Wa

IPC分类号： C07D233/64 ,  A61K31/415

CPC分类号： C07D233/64 ,  A61K31/445 ,  A61K31/495 ,  A61K31/415 ,  A61K2300/00

摘要： Disclosed are novel phenyl-alkyl-imidazoles of formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein A and R, are as defined in the specification. Also disclosed are methods of treating allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper and hypo motility of the gastrointestinal tract, hypo and hyperactivity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines, comprising administering an effective amount of a compound of formula (I) (or a salt or solvate thereof) to a patient in need of such treatment. Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula (I) in combination or admixture with a histamine H1 receptor antagonist.

公开(公告)号：EP1028947A1

公开(公告)日：2000-08-23

申请号：EP98956442.2

申请日：1998-11-05

申请人： SCHERING CORPORATION

发明人： ASLANIAN, Robert, G. ,  McCORMICK, Kevin, D. ,  MUTAHI, Mwangi, Wa

IPC分类号： C07D233/64 ,  A61K31/415

CPC分类号： C07D233/64 ,  A61K31/445 ,  A61K31/495 ,  A61K31/415 ,  A61K2300/00

摘要： Disclosed are novel phenyl-alkyl-imidazoles of formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein A and R, are as defined in the specification. Also disclosed are methods of treating allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper and hypo motility of the gastrointestinal tract, hypo and hyperactivity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines, comprising administering an effective amount of a compound of formula (I) (or a salt or solvate thereof) to a patient in need of such treatment. Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula (I) in combination or admixture with a histamine H1 receptor antagonist.

公开(公告)号：EP1326858B1

公开(公告)日：2005-12-14

申请号：EP01983968.7

申请日：2001-10-15

申请人： SCHERING CORPORATION

发明人： ASLANIAN, Robert, G. ,  SHIH, Neng-Yang ,  TING, Pauline, C. ,  BERLIN, Michael, Y. ,  ROSENBLUM, Stuart, B. ,  MC CORMICK, Kevin, D. ,  TOM, Wing, C. ,  BOYCE, Christopher, W. ,  MANGIARACINA, Pietro ,  MUTAHI, Mwangi, Wa ,  PIWINSKI, John, J.

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D401/12 ,  C07D409/14 ,  C07D498/04 ,  C07D417/14

CPC分类号： C07D213/73 ,  A61K31/435 ,  A61K31/445 ,  A61K31/495 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

公开(公告)号：EP1373251A2

公开(公告)日：2004-01-02

申请号：EP02709808.6

申请日：2002-03-11

申请人： Schering Corporation ,  PHARMACOPEIA, INC.

发明人： ROSENBLUM, Stuart, B. ,  ZENG, Qingbei ,  MUTAHI, Mwangi, Wa ,  ASLANIAN, Robert, G. ,  TING, Pauline, C. ,  SHIH, Neng-Yang ,  SOLOMON, Daniel, M. ,  CAO, Jianhua ,  VACCARO, Henry, A. ,  MC CORMICK, Kevin, D. ,  BALDWIN, John, J. ,  LI, Ge

IPC分类号： C07D401/14

CPC分类号： C07D401/14 ,  C07D211/26 ,  C07D211/38 ,  C07D211/62 ,  C07D211/96 ,  C07D243/08 ,  C07D401/06 ,  C07D407/12 ,  C07D407/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D451/02 ,  C07D487/06

摘要： Disclosed are novel compounds of the formula (I). Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I). Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula (I). Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula (I) in combination with a H1 receptor antagonist.