公开(公告)号：EP4169514A1

公开(公告)日：2023-04-26

申请号：EP22193944.0

申请日：2018-07-31

申请人： Scynexis, Inc.

发明人： ANGULO GONZALEZ, David A.

IPC分类号： A61K31/4196 ,  A61K31/4439 ,  A61P31/10 ,  A61P15/02

摘要： Enfumafungin derivative triterpenoid antifungal compounds are used to treat or prevent fungal infections occurring in or under acidic conditions where the pH is lower than about 7, due to their unexpected, enhanced efficacy under such conditions. The enfumafungin derivative triterpenoids (or pharmaceutically acceptable salts or hydrates thereof) are inhibitors of (1,3)-β-D-glucan synthesis and are useful in the treatment or prevention of yeast or mold infections that occur in anatomic areas having a low pH, such as the vaginal cavity, or under acidic local environment conditions such of those seen in fungal abscesses, empyema, or upper gastrointestinal tract infections.

公开(公告)号：EP3609539A1

公开(公告)日：2020-02-19

申请号：EP18720489.6

申请日：2018-04-04

申请人： Scynexis, Inc.

发明人： ANGULO GONZALEZ, David A.

IPC分类号： A61K45/06 ,  A61K31/4196 ,  A61K31/4439 ,  A61P31/10

公开(公告)号：EP3968986A1

公开(公告)日：2022-03-23

申请号：EP20728876.2

申请日：2020-05-12

申请人： Scynexis, Inc.

发明人： ANGULO GONZALEZ, David A. ,  BARAT, Stephen Andrew

IPC分类号： A61K31/4196 ,  A61K31/4439 ,  A61P31/10

公开(公告)号：EP3930716A1

公开(公告)日：2022-01-05

申请号：EP20714386.8

申请日：2020-02-25

申请人： Scynexis, Inc.

发明人： ANGULO GONZALEZ, David A. ,  BARAT, Stephen Andrew

IPC分类号： A61K31/4439 ,  A61P11/00 ,  A61P31/10

公开(公告)号：EP3917534A1

公开(公告)日：2021-12-08

申请号：EP20708913.7

申请日：2020-01-30

申请人： Scynexis, Inc.

发明人： ANGULO GONZALEZ, David A.

IPC分类号： A61K31/56 ,  A61P31/10