公开(公告)号：EP1487555A1

公开(公告)日：2004-12-22

申请号：EP03711159.8

申请日：2003-02-20

申请人： Selerity Technologies, Inc.

发明人： JONES, Brian ,  PORTER, Nathan, L.

IPC分类号： B01D15/08

CPC分类号： B01D15/161 ,  G01N30/30 ,  G01N2030/3007 ,  G01N2030/3023 ,  G01N2030/303 ,  G01N2030/3038 ,  G01N2030/3046

摘要： A convenient and efficient method for heating or cooling the mobile phase fluid of a chromatographic system prior to its entry into the chromatographic column (16) is described. The “preheating” or “precooling” process is carried out using an apparatus (10) containing a short length of tubing (11) where the mobile phase is heated or cooled. The heating or cooling is performed using a heating or cooling element (12) that is in intimate thermal contact with the exterior of the tubing (11). With a low mass heating or cooling element (12), the device can be very responsive and allows for rapid equilibration and convenient temperature programming of the mobile phase. This configuration also requires only a short mobile phase contact time, is non-invasive, adds no dead volume, and allows for use of columns over a wide range of internal diameter, flow rates and temperatures.