公开(公告)号：EP1752152A1

公开(公告)日：2007-02-14

申请号：EP05743700.6

申请日：2005-05-30

申请人： Senju Pharmaceutical Co., Ltd.

发明人： MATSUHISA, Keiichi ,  INOUE, Yutaka

IPC分类号： A61K31/718 ,  A61K31/722 ,  A61K31/765 ,  A61K45/00 ,  A61P27/02 ,  A61P27/12

CPC分类号： A61K31/718 ,  A61K9/0048 ,  A61K31/722 ,  A61K31/765 ,  A61K49/0091 ,  A61K2300/00

摘要： Described is a highly safe means to improve visibility of transparent tissues of the eye, i.e., the vitreous body, the lens or the cornea, in a surgical operation on them. The means comprises fine particles of a macromolecular compound, in particular, those one gram of which cannot be dissolved in less than 30 mL of water within 30 minutes at 20 °C, and whose average particle size is 0.01-500 µm, and which, among others, is a biodegradable macromolecular compound and/or a water soluble macromolecular compound.

摘要翻译： 描述的是在其外科手术中改善眼睛的透明组织，即玻璃体，晶状体或角膜的可视性的高度安全的手段。 该方法包括高分子化合物的细颗粒，特别是在20℃下在30分钟内不能溶解在少于30mL水中的那些1g，平均粒径为0.01-500μm， 是一种可生物降解的高分子化合物和/或水溶性大分子化合物。

公开(公告)号：EP1752158A1

公开(公告)日：2007-02-14

申请号：EP05734734.6

申请日：2005-04-21

申请人： Senju Pharmaceutical Co., Ltd. ,  Itoham Foods Inc.

发明人： TAKAYAMA, Yoshiko; ,  NAKAMURA, Yoshikuni; ,  INOUE, Yutaka ,  YABUTA, Chiho ,  AZUMA, Mitsuyoshi ,  ONOUE, Satomi

IPC分类号： A61K38/00 ,  A61P27/02

CPC分类号： A61K38/2278

摘要： It is intended to provide an agent for promoting corneal neuritogenesis containing PACAP, a PACAP derivative or a pharmaceutically acceptable salt thereof, in particular, an agent for promoting corneal neuritogenesis aiming at improving corneal sensitivity, treating dry eye and treating corneal epithelial injury due to an effect of promoting corneal neuritogenesis. This agent for promoting corneal neuritogenesis is useful as a drug for ameliorating reduction in corneal sensitivity following corneal surgeries such as laser keratonomy (LASIK) and corneal grafting or cataract surgery, reduction in corneal sensitivity accompanying corneal neurodegeneration and dry eye symptom and corneal epithelial injury accompanying such reduction in corneal sensitivity. Moreover, it is useful as a drug for ameliorating dry eye symptom, reduction in corneal sensitivity and corneal epithelial injury in patients with dry eye, and a drug for ameliorating corneal epithelial injury and dry eye symptom and reduction in corneal sensitivity accompanying therewith.

摘要翻译： 旨在提供用于促进包含PACAP，PACAP衍生物或其药学上可接受的盐的角膜神经发生的药剂，特别是用于促进角膜神经发生的药物，其目的在于改善角膜敏感性，治疗干眼症并治疗角膜上皮损伤 促进角膜神经发生的作用。 用于促进角膜神经发生的这种药物可用作改善角膜手术如角膜手术（LASIK）和角膜移植术或白内障手​​术后角膜敏感性降低的药物，伴随角膜神经变性和干眼症状以及角膜上皮损伤伴随的角膜敏感性降低 角膜敏感度降低。 此外，作为用于改善干眼症症状的患者，干眼症患者角膜敏感性和角膜上皮损伤降低药物以及用于改善角膜上皮损伤和干眼症状以及随之伴随的角膜敏感性降低的药物是有用的。

公开(公告)号：EP1043322B1

公开(公告)日：2002-05-08

申请号：EP98961437.5

申请日：1998-12-18

申请人： Senju Pharmaceutical Co., Ltd.

发明人： OGATA, Kazumi ,  NAKAO, Hidetoshi ,  ITO, Kazuhiko ,  SAKAUE, Takahiro ,  IEMURA, Masahito ,  INOUE, Yutaka

IPC分类号： C07D311/72 ,  C07D405/12 ,  C07K5/02 ,  A61K31/355 ,  A61K31/40 ,  A61K38/05 ,  A61K38/06 ,  A61K7/00 ,  A61P1/16

CPC分类号： C07D405/12 ,  A61K8/678 ,  A61K38/00 ,  A61Q19/00 ,  C07D311/72 ,  C07K5/0215

公开(公告)号：EP1043322A1

公开(公告)日：2000-10-11

申请号：EP98961437.5

申请日：1998-12-18

申请人： Senju Pharmaceutical Co., Ltd.

发明人： OGATA, Kazumi ,  NAKAO, Hidetoshi ,  ITO, Kazuhiko ,  SAKAUE, Takahiro ,  IEMURA, Masahito ,  INOUE, Yutaka

IPC分类号： C07D311/72 ,  C07D405/12 ,  C07K5/02 ,  A61K31/355 ,  A61K31/40 ,  A61K38/05 ,  A61K38/06 ,  A61K7/00

CPC分类号： C07D405/12 ,  A61K8/678 ,  A61K38/00 ,  A61Q19/00 ,  C07D311/72 ,  C07K5/0215

摘要： Novel vitamin E derivatives represented by general formula (I) or pharmacologically acceptable salts thereof which are useful as hepatopathy inhibitors, anticataract agents, cerebral metabolism activators, antioxidants and cosmetic components. In Formula (I), R 1 and R 2 are the same or different and each represents hydrogen or methyl; R 3 represents an SH compound bonded via an S-bond selected from among glutathione, γ-glutamylcysteine, cysteine, penicillamine, esters thereof and cysteamine, and R 4 represents hydroxy, an N-substituted amino acid selected from among glycine, β-alanine, γ-aminobutyric acid, 5-aminovaleric acid, ε-aminocaproic acid, anthranilic acid, tranexamic acid, proline, esters thereof, aminoethylsulfonic acid and aminoethylsulfinic acid, or serotonin.

摘要翻译： 由通式（I）表示的新型维生素E衍生物或其药理学上可接受的盐，其可用作肝病抑制剂，抗龋齿剂，脑代谢活化剂，抗氧化剂和美容成分。 在式（I）中，R 1和R 2相同或不同，各自表示氢或甲基; R3表示通过选自谷胱甘肽，γ-谷氨酰半胱氨酸，半胱氨酸，青霉胺，其酯和半胱胺中的S-键键合的SH化合物，R4表示羟基，选自甘氨酸，β-丙氨酸，γ-氨基丁酸的N-取代氨基酸 氨基丁酸，5-氨基戊酸，ε-氨基己酸，邻氨基苯甲酸，氨甲环酸，脯氨酸，其酯，氨基乙基磺酸和氨基乙基亚磺酸，或5-羟色胺。