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    RATIONALE, METHODS, AND ASSAYS FOR IDENTIFYING HUMAN AND NON-HUMAN PRIMATE TASTE SPECIFIC GENES AND USE THEREOF IN TASTE MODULATOR AND THERAPEUTIC SCREENING ASSAYS
    3.
    发明公开
    RATIONALE, METHODS, AND ASSAYS FOR IDENTIFYING HUMAN AND NON-HUMAN PRIMATE TASTE SPECIFIC GENES AND USE THEREOF IN TASTE MODULATOR AND THERAPEUTIC SCREENING ASSAYS 审中-公开
    基本原理，方法和用于鉴定人类和非人类灵长类动物TASTE特定基因及其用途的口味调制器和治疗的筛选分析

    公开(公告)号：EP2164976A2

    公开(公告)日：2010-03-24

    申请号：EP08768178.9

    申请日：2008-06-06

    申请人： Senomyx, Inc.

    发明人： MOYER, Bryan ,  ZLOTNIK, Albert ,  HEVEZI, Peter ,  SOTO, Hortensia ,  KALABAT, Dalia ,  LU, Min ,  GAO, Na ,  WHITE, Evan

    IPC分类号： C12Q1/00 ,  C12N15/00

    CPC分类号： G01N33/566 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C40B30/04 ,  C40B40/10 ,  G01N33/5005 ,  G01N33/5044 ,  G01N33/6872 ,  G01N2333/726 ,  G01N2500/10

    摘要： This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.

    摘要翻译： 识别人类和灵长类动物特定的味道基因，包括参与咸，甜，苦，鲜味的基因，和酸味感觉，尤其是人类咸味的感知，以及基因参与其他味觉细胞或味觉受体的相关活动，如消化功能的方法 和消化相关疾病，味细胞更新，口腔和消化道的免疫调节以及代谢调节如糖尿病和肥胖症。 还公开了使用这些方法鉴定的基因和用于鉴定味觉调节剂（增强剂或阻断剂）的试验以及使用这些基因的潜在治疗剂。

    IDENTIFICATION OF TRPML3 (MCOLN3) AS A SALTY TASTE RECEPTOR AND USE IN ASSAYS FOR IDENTIFYING TASTE (SALTY) MODULATORS AND/OR THERAPEUTICS THAT MODULATE SODIUM TRANSPORT, ABSORPTION OR EXCRETION AND/OR ALDOSTERONE AND/OR VASOPRESSIN PRODUCTION OR RELEASE
    4.
    发明公开
    IDENTIFICATION OF TRPML3 (MCOLN3) AS A SALTY TASTE RECEPTOR AND USE IN ASSAYS FOR IDENTIFYING TASTE (SALTY) MODULATORS AND/OR THERAPEUTICS THAT MODULATE SODIUM TRANSPORT, ABSORPTION OR EXCRETION AND/OR ALDOSTERONE AND/OR VASOPRESSIN PRODUCTION OR RELEASE 审中-公开
    鉴定作为盐味受体的TRPML3（MCOLN3）以及用于鉴定调节钠转运，吸收或排泄和/或醛固酮和/或血管收缩素产生或释放的味觉（盐）调节剂和/或治疗剂的试验中的用途

    公开(公告)号：EP2167643A2

    公开(公告)日：2010-03-31

    申请号：EP08826211.8

    申请日：2008-06-06

    申请人： Senomyx, Inc.

    发明人： MOYER, Bryan ,  ZLOTNIK, Albert ,  HEVEZI, Peter ,  SOTO, Hortensia ,  LU, Min ,  GAO, Na ,  SERVANT, Guy ,  BRUST, Paul ,  WILLIAMS, Mark ,  KALABAT, Dalia ,  WHITE, Evan, Carl ,  LAITA, Bianca ,  DAHAN, David ,  SAGANICH, Michael

    IPC分类号： C12N5/00

    CPC分类号： G01N33/566 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C40B30/04 ,  C40B40/10 ,  G01N33/5005 ,  G01N33/5044 ,  G01N33/6872 ,  G01N2333/726 ,  G01N2500/10

    摘要： This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.

    摘要翻译： 用于鉴定人TRPML3调节剂，优选TRPML3增强剂的高通量哺乳动物和中等通量的基于卵母细胞的电生理学测定法公开了在测定法中调节TRPML3功能的化合物预期会影响人类的咸味。电生理学测定法，诸如双电极 电压钳技术，有助于鉴定特异性调节人TRPML3的化​​合物。该测定法提供了用于检测促进（增强）或抑制TRPML3功能并由此调节咸味的化合物的有力筛选。此外，这些化合物可用于调节钠 排泄，泌尿量和其他与钠水平有关的生物学功能