公开(公告)号：EP3132810A1

公开(公告)日：2017-02-22

申请号：EP15779986.7

申请日：2015-04-17

申请人： Seoul National University R&DB Foundation ,  Baiksan Co., Ltd.

发明人： CHOI, Tae Hyun ,  LEE, Yan ,  PARK, Ji Ung ,  HAM, Ji Yeon ,  KIM, Hee Jin ,  KIM, Suk Wha ,  MIN, Hye Jeong

IPC分类号： A61L27/34 ,  A61L27/32 ,  A61F2/12

CPC分类号： A61F2/12 ,  A61F2/0059 ,  A61L27/32 ,  A61L27/34 ,  A61L2300/216 ,  A61L2400/18 ,  A61L2430/04 ,  B05D1/02

摘要： The present invention relates to a coating composition for an in-vivo implantable prosthesis including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group, a method of coating an in-vivo implantable prosthesis using the coating composition, and a cosmetic prosthesis coated with the crosslinked polyphosphorylcholine.
An in-vivo implantable prosthesis coated with crosslinked polyphosphorylcholine may be manufactured by a simple method of applying a coating composition including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group according to the present invention, and then irradiating UV rays. The crosslinked polyphosphorylcholine coating may provide hydrophilicity for the surface and may also remarkably reduce adsorption of proteins and fibroblasts, which may cause side effects such as capsular contracture. Further, the coating has strong enough not to peel off even under stimulation, and therefore, it is maintained under vigorous activity after implantation, thereby being usefully applied to the manufacture of an in-vivo implantable prosthesis with reduced side effects, such as breast prosthesis for cosmetic surgery.

摘要翻译： 本发明涉及一种用于体内可植入假体的涂料组合物，其包括光引发剂，交联剂和具有丙烯酸酯基团的磷酸胆碱（PC）单体，使用该涂料组合物涂覆体内可植入假体的方法， 以及涂覆有交联的聚磷酰胆碱的化妆品假体。 涂布有交联聚磷酰胆碱的体内可植入假体可以通过施加包含光引发剂，交联剂和具有本发明的具有丙烯酸酯基团的磷酸胆碱（PC）单体的涂料组合物的简单方法制造，然后照射 紫外线。 交联的聚磷酰胆碱涂层可以为表面提供亲水性，并且还可以显着降低蛋白质和成纤维细胞的吸附，这可能引起副作用如荚膜挛缩。 此外，涂层即使在刺激下也足够坚固，不会剥离，因此在植入后保持活跃的活性，从而可用于制造具有减少的副作用的体内可植入假体，例如乳房假体 用于整容手术。

公开(公告)号：EP3011963A1

公开(公告)日：2016-04-27

申请号：EP14813786.2

申请日：2014-04-30

申请人： Seoul National University R&DB Foundation

发明人： CHOI, Tae Hyun ,  PIAO, Ying-lan ,  KIM, Suk Wha ,  HUR, Woojune ,  CHOI, La Mee ,  MIN, Hye Jeong

IPC分类号： A61K35/74 ,  A61K35/66 ,  A61P17/00 ,  A61P21/00

CPC分类号： A61K38/4893 ,  A61K8/64 ,  A61K8/66 ,  A61K9/0019 ,  A61K47/36 ,  A61K2800/91 ,  A61Q19/08 ,  C12Y304/24069

摘要： The present invention discloses a composition comprising a filler and Botulinum toxin for alleviating skin wrinkles or aging or treating neuromuscular diseases. The composition according to the present invention resolves neuromuscular diseases, aging or skin wrinkles caused by two types of causative factors through a single injection. At the same time, the composition according to the present invention has a synergistic effect by which one component improves the efficacy of another component. Therefore, the number of injections is decreased to thereby enhance the convenience of patients and reduce costs.

摘要翻译： 本发明盘松一组合物，包含用于减轻皮肤皱纹或老化或治疗神经肌肉疾病的填料和肉毒毒素。 该组合物gemäß到本发明解决了神经肌肉疾病，老化或皮肤皱纹通过单次注射由两种类型的致病因素引起的。 在在Sametime，组合物gemäß到本发明已经通过其一个部件改善另一种组分的功效的协同作用。 因此，注射的次数减少，从而提高患者的便利性和降低成本。