公开(公告)号：EP2552888B1

公开(公告)日：2018-09-26

申请号：EP10799032.7

申请日：2010-12-22

申请人： Serentrix, LLC

发明人： NAPOLETANO, Mauro ,  TREVISANI, Marcello ,  PAVANI, Maria Giovanna ,  FRUTTAROLO, Francesca

IPC分类号： C07D209/32 ,  C07D235/26 ,  C07D263/58 ,  C07D265/36 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/538 ,  A61P29/00 ,  A61P11/00 ,  A61P13/00 ,  A61P17/00

CPC分类号： C07D413/14 ,  C07D209/34 ,  C07D235/26 ,  C07D263/58 ,  C07D265/36 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

摘要： The invention discloses compounds of formula I wherein Y s selected from a group of formula and W, Q, n, R1, R2, R3, U1-U5 have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1. 1.