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公开(公告)号：EP1706132B1
公开(公告)日：2011-03-23
申请号：EP04808335.6
申请日：2004-12-07
发明人： CHANG, Cheong-Ho , KO, Chang-Kwon, 110-2002 Dongbu centrebill Apt , JANG, Jae-Deog , LEE, Eun-Young , CHOI, Jeong-Yong
IPC分类号： A61K38/16
CPC分类号： A61K35/32 , A61F2/30756 , A61K35/36 , A61K35/39 , A61L27/225 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61K2300/00
摘要： The present invention relates to a cartilage therapeutic composition, capable of being clinically transplanted to articulatio genu (knee joint) or ankle joints, in particular clinically significant, symptomatic cartilage defects of the femoral condyle (medial, lateral, or trochlear) and bone cartilage defects of the talus (anklebone) in human or animal hosts, and a method of using the same. The cartilage therapeutic composition in accordance with the present invention comprises a mixture of components of chondrocytes isolated and expanded or differentiated from a host such as human or animal, and thrombin and a fibrinogen matrix containing fibrinogen. Further, provided is a method of using the cartilage therapeutic composition such that a mixture of thrombin, chondrocyte components and a fibrinogen matrix is injected to a cartilage defect region followed by solidification therein. Therefore, in accordance with the present invention, it is possible to promote rapid and effective regeneration of cartilage without imposing excessive burden associated with a surgical operation, and to realize a safe and simplified process by using an arthroscope for transplantation.
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2.发明授权SIMPLE METHOD OF TRANSPLANTING INJECTABLE CHONDROCYTE FOR AUTOLOGOUS CHONDROCYTE TRANSPLANTATION 有权自体软骨细胞移植移植注射用软骨细胞的简便方法
公开(公告)号：EP1912661B1
公开(公告)日：2011-03-16
申请号：EP05809011.9
申请日：2005-09-23
发明人： KO, Chang-Kwon , LEE, Eun-Young , CHOI, Jeong-Yong , JANG, Jae-Deog , CHANG, Cheong-Ho , KIM, Pyoung-Min
CPC分类号： A61K38/363 , A61K38/39 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L2430/06 , A61K2300/00
摘要： The present invention relates to a method of transplanting an injectable chondrocyte for autologous chondrocyte transplantation. For this purpose, the present invention provides a method of transplanting an injectable chondrocyte for autologous chondrocyte transplantation, comprising mixing matrices including fibrin, hyaluronic acid and collagen, constituting main ingredients of animal cartilage, via use of a front end mixing tip of a syringe, while injecting the resulting mixture into a damaged cartilage region. The present invention having the above-mentioned construction provides advantageous effects such as solution of inconvenience exhibited by conventional osteoperiosteal grafting, by mixing and transplanting matrices including fibrin, hyaluronic acid and collagen which are main ingredients of cartilage; treatment of a wide variety of cartilage defects and severe osteoarthritis; alleviation of burden of patients to be treated via a simplified surgical operation method; and thereby promotion of rapider and more effective cartilage generation, resulting in improved customer satisfaction.
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公开(公告)号：EP1706132A1
公开(公告)日：2006-10-04
申请号：EP04808335.6
申请日：2004-12-07
发明人： CHANG, Cheong-Ho , KO, Chang-Kwon, 110-2002 Dongbu centrebill Apt , JANG, Jae-Deog , LEE, Eun-Young , CHOI, Jeong-Yong
IPC分类号： A61K38/16
CPC分类号： A61K35/32 , A61F2/30756 , A61K35/36 , A61K35/39 , A61L27/225 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61K2300/00
摘要： The present invention relates to a cartilage therapeutic composition, capable of being clinically transplanted to articulatio genu (knee joint) or ankle joints, in particular clinically significant, symptomatic cartilage defects of the femoral condyle (medial, lateral, or trochlear) and bone cartilage defects of the talus (anklebone) in human or animal hosts, and a method of using the same. The cartilage therapeutic composition in accordance with the present invention comprises a mixture of components of chondrocytes isolated and expanded or differentiated from a host such as human or animal, and thrombin and a fibrinogen matrix containing fibrinogen. Further, provided is a method of using the cartilage therapeutic composition such that a mixture of thrombin, chondrocyte components and a fibrinogen matrix is injected to a cartilage defect region followed by solidification therein. Therefore, in accordance with the present invention, it is possible to promote rapid and effective regeneration of cartilage without imposing excessive burden associated with a surgical operation, and to realize a safe and simplified process by using an arthroscope for transplantation.
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公开(公告)号：EP2004797A1
公开(公告)日：2008-12-24
申请号：EP06716405.3
申请日：2006-03-16
发明人： JUNG, Soo-Jin , SUH, Dong-Sam , KO, Chang-Kwon , RYU, Seung-Ju , KOH, Sung-Jun , LEE, Eun-Young , CHANG, Dong-Il , LEE, Jun-Keun , YOON, Hyun-Gi , CHANG, Hyang-Soon , YOO, Yong-Hyun , CHUNG, Jin-Wook , CHANG, Cheong-Ho
IPC分类号： C12M3/00
摘要： Provided is a facility module for production and storage of a cell therapy product. For this purpose, the facility module is comprised of a CT (Cell Therapy) -module 1 including a plurality of separately prefabricated units having individual-specific functions and having separately partitioned entrance and exit so as to minimize occurrence of contamination, and being capable of producing the cell therapy product, and a BC (Banking of Cell and Tissue)-module 2 including a plurality of separately prefabricated units having individual- specific functions and having separately partitioned entrance and exit so as to minimize occurrence of contamination, and being capable of storing hematopoietic stem cells and bone marrow cells and other cells for a prolonged period of time through appropriate processes.
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5.发明公开SIMPLE METHOD OF TRANSPLANTING INJECTABLE CHONDROCYTE FOR AUTOLOGOUS CHONDROCYTE TRANSPLANTATION 有权自体软骨细胞移植移植注射用软骨细胞的简便方法
公开(公告)号：EP1912661A1
公开(公告)日：2008-04-23
申请号：EP05809011.9
申请日：2005-09-23
发明人： KO, Chang-Kwon , LEE, Eun-Young , CHOI, Jeong-Yong , JANG, Jae-Deog , CHANG, Cheong-Ho , KIM, Pyoung-Min
IPC分类号： A61K35/32
CPC分类号： A61K38/363 , A61K38/39 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L2430/06 , A61K2300/00
摘要： The present invention relates to a method of transplanting an injectable chondrocyte for autologous chondrocyte transplantation. For this purpose, the present invention provides a method of transplanting an injectable chondrocyte for autologous chondrocyte transplantation, comprising mixing matrices including fibrin, hyaluronic acid and collagen, constituting main ingredients of animal cartilage, via use of a front end mixing tip of a syringe, while injecting the resulting mixture into a damaged cartilage region. The present invention having the above-mentioned construction provides advantageous effects such as solution of inconvenience exhibited by conventional osteoperiosteal grafting, by mixing and transplanting matrices including fibrin, hyaluronic acid and collagen which are main ingredients of cartilage; treatment of a wide variety of cartilage defects and severe osteoarthritis; alleviation of burden of patients to be treated via a simplified surgical operation method; and thereby promotion of rapider and more effective cartilage generation, resulting in improved customer satisfaction.
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