公开(公告)号：EP1991292B1

公开(公告)日：2018-07-04

申请号：EP06716374.1

申请日：2006-03-15

申请人： Sewon Cellontech Co., Ltd.

发明人： SON, Hyun-Mi ,  JANG, Jae-Deog ,  CHANG, Cheong-Ho

IPC分类号： A61K35/35 ,  A61M39/10 ,  A61B50/31 ,  A61B50/30

CPC分类号： A61K35/35 ,  A61B50/31 ,  A61B2050/3008 ,  A61B2050/3011 ,  A61M39/10

摘要： A device and method for regenerating adipose tissue has developed comprising: a washing container filled with an sterile solution for washing the adipose tissues; a syringe container holding syringes for washing and separating adipose tissues; injecting the wash solution and mixing the Bio-Gel, respectively; a second syringe container containing Bio-Gel syringes filled with materials to induce adipogenesis; and connector containers holding connectors for injection of the wash solution, and mixing of washed tissues and Bio-Gel. These containers are restrained in the kit by grooves in the bottom of the box. The box top holds needle containers for transplantation needles; and a protocol for fat transplantation, restrained by grooves. The kit minimizes risk of infection in fat transplantations using the patient's own tissues. It enables stable tissue transplantation as well as adipose tissue regeneration via use of aseptic/sterile implements, and a protocol for fat transplantation, solving the problems associated with conventional adipose tissue transplantation.

公开(公告)号：EP1896044A1

公开(公告)日：2008-03-12

申请号：EP05765896.5

申请日：2005-06-27

申请人： Sewon Cellontech Co., Ltd.

发明人： JANG, Jae-Deog ,  PARK, Hyun-Shin ,  CHANG, Cheong-Ho ,  JUNG, Soo-Jin, 301-1103 Sinmyoung APT ,  LEE, Sae-Bom ,  KO, Chang-Kwon

IPC分类号： A61K35/28

CPC分类号： A61K35/32 ,  A61K35/12 ,  A61K38/4833 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/3895 ,  A61L2430/02 ,  C12N5/0654 ,  C12N2533/56

摘要： Provided is a composition for bone formation using a mixture of an osteoblast and a bio-matrix, and a method for preparing the same. The methods comprises isolating osteoblasts from a bone tissue and culturing/proliferating the isolated osteoblasts in DMEM (Dulbecco's Modified Eagle's Medium) or α-MEM (Minimum Essential Medium, Alpha Modification) to prepare an osteoblast suspension; and mixing the resulting osteoblast suspension with a bio-matrix to prepare an osteoblast therapeutic agent. In accordance with the present invention, it is possible to realize a bone formation method, resulting in no clinical graft rejection via injection of an osteoblast and bio-matrix mixture for bone formation into a site where bone formation is sought, and being capable of achieving effective and rapid bone formation via injection of a composition which was shaped to a certain extent, so as to alleviate problems associated with probability of bone tissue formation in unwanted regions resulting from escape of injected osteoblasts from the targeted site for bone formation and then propagation thereof to other sites via the blood stream, which are caused by injection of an osteoblast suspension.

公开(公告)号：EP1896044B1

公开(公告)日：2011-03-23

申请号：EP05765896.5

申请日：2005-06-27

申请人： Sewon Cellontech Co., Ltd.

发明人： JANG, Jae-Deog ,  PARK, Hyun-Shin ,  CHANG, Cheong-Ho ,  JUNG, Soo-Jin, 301-1103 Sinmyoung APT ,  LEE, Sae-Bom ,  KO, Chang-Kwon

IPC分类号： C12N5/071

CPC分类号： A61K35/32 ,  A61K35/12 ,  A61K38/4833 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/3895 ,  A61L2430/02 ,  C12N5/0654 ,  C12N2533/56

摘要： Provided is a composition for bone formation using a mixture of an osteoblast and a bio-matrix, and a method for preparing the same. The methods comprises isolating osteoblasts from a bone tissue and culturing/proliferating the isolated osteoblasts in DMEM (Dulbecco's Modified Eagle's Medium) or α-MEM (Minimum Essential Medium, Alpha Modification) to prepare an osteoblast suspension; and mixing the resulting osteoblast suspension with a bio-matrix to prepare an osteoblast therapeutic agent. In accordance with the present invention, it is possible to realize a bone formation method, resulting in no clinical graft rejection via injection of an osteoblast and bio-matrix mixture for bone formation into a site where bone formation is sought, and being capable of achieving effective and rapid bone formation via injection of a composition which was shaped to a certain extent, so as to alleviate problems associated with probability of bone tissue formation in unwanted regions resulting from escape of injected osteoblasts from the targeted site for bone formation and then propagation thereof to other sites via the blood stream, which are caused by injection of an osteoblast suspension.

公开(公告)号：EP2004797A1

公开(公告)日：2008-12-24

申请号：EP06716405.3

申请日：2006-03-16

申请人： Sewon Cellontech Co., Ltd.

发明人： JUNG, Soo-Jin ,  SUH, Dong-Sam ,  KO, Chang-Kwon ,  RYU, Seung-Ju ,  KOH, Sung-Jun ,  LEE, Eun-Young ,  CHANG, Dong-Il ,  LEE, Jun-Keun ,  YOON, Hyun-Gi ,  CHANG, Hyang-Soon ,  YOO, Yong-Hyun ,  CHUNG, Jin-Wook ,  CHANG, Cheong-Ho

IPC分类号： C12M3/00

CPC分类号： F24F3/0442 ,  C12M23/44 ,  C12M37/00 ,  C12M37/06 ,  C12M41/14 ,  C12M45/22 ,  F24F3/161

摘要： Provided is a facility module for production and storage of a cell therapy product. For this purpose, the facility module is comprised of a CT (Cell Therapy) -module 1 including a plurality of separately prefabricated units having individual-specific functions and having separately partitioned entrance and exit so as to minimize occurrence of contamination, and being capable of producing the cell therapy product, and a BC (Banking of Cell and Tissue)-module 2 including a plurality of separately prefabricated units having individual- specific functions and having separately partitioned entrance and exit so as to minimize occurrence of contamination, and being capable of storing hematopoietic stem cells and bone marrow cells and other cells for a prolonged period of time through appropriate processes.

公开(公告)号：EP1912661A1

公开(公告)日：2008-04-23

申请号：EP05809011.9

申请日：2005-09-23

申请人： Sewon Cellontech Co., Ltd.

发明人： KO, Chang-Kwon ,  LEE, Eun-Young ,  CHOI, Jeong-Yong ,  JANG, Jae-Deog ,  CHANG, Cheong-Ho ,  KIM, Pyoung-Min

IPC分类号： A61K35/32

CPC分类号： A61K38/363 ,  A61K38/39 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/50 ,  A61L2430/06 ,  A61K2300/00

摘要： The present invention relates to a method of transplanting an injectable chondrocyte for autologous chondrocyte transplantation. For this purpose, the present invention provides a method of transplanting an injectable chondrocyte for autologous chondrocyte transplantation, comprising mixing matrices including fibrin, hyaluronic acid and collagen, constituting main ingredients of animal cartilage, via use of a front end mixing tip of a syringe, while injecting the resulting mixture into a damaged cartilage region. The present invention having the above-mentioned construction provides advantageous effects such as solution of inconvenience exhibited by conventional osteoperiosteal grafting, by mixing and transplanting matrices including fibrin, hyaluronic acid and collagen which are main ingredients of cartilage; treatment of a wide variety of cartilage defects and severe osteoarthritis; alleviation of burden of patients to be treated via a simplified surgical operation method; and thereby promotion of rapider and more effective cartilage generation, resulting in improved customer satisfaction.

公开(公告)号：EP2018419B1

公开(公告)日：2016-05-04

申请号：EP06769014.9

申请日：2006-06-23

申请人： Sewon Cellontech Co., Ltd.

发明人： PARK, Hyun-Shin ,  JANG, Jae-Deog ,  LEE, Sae-Bom ,  CHANG, Cheong-Ho

IPC分类号： C12N5/00

CPC分类号： C12N5/0654 ,  A61K35/28

公开(公告)号：EP1706132B1

公开(公告)日：2011-03-23

申请号：EP04808335.6

申请日：2004-12-07

申请人： Sewon Cellontech Co., Ltd.

发明人： CHANG, Cheong-Ho ,  KO, Chang-Kwon, 110-2002 Dongbu centrebill Apt ,  JANG, Jae-Deog ,  LEE, Eun-Young ,  CHOI, Jeong-Yong

IPC分类号： A61K38/16

CPC分类号： A61K35/32 ,  A61F2/30756 ,  A61K35/36 ,  A61K35/39 ,  A61L27/225 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/3895 ,  A61K2300/00

摘要： The present invention relates to a cartilage therapeutic composition, capable of being clinically transplanted to articulatio genu (knee joint) or ankle joints, in particular clinically significant, symptomatic cartilage defects of the femoral condyle (medial, lateral, or trochlear) and bone cartilage defects of the talus (anklebone) in human or animal hosts, and a method of using the same. The cartilage therapeutic composition in accordance with the present invention comprises a mixture of components of chondrocytes isolated and expanded or differentiated from a host such as human or animal, and thrombin and a fibrinogen matrix containing fibrinogen. Further, provided is a method of using the cartilage therapeutic composition such that a mixture of thrombin, chondrocyte components and a fibrinogen matrix is injected to a cartilage defect region followed by solidification therein. Therefore, in accordance with the present invention, it is possible to promote rapid and effective regeneration of cartilage without imposing excessive burden associated with a surgical operation, and to realize a safe and simplified process by using an arthroscope for transplantation.

公开(公告)号：EP1991292A1

公开(公告)日：2008-11-19

申请号：EP06716374.1

申请日：2006-03-15

申请人： Sewon Cellontech Co., Ltd.

发明人： SON, Hyun-Mi ,  JANG, Jae-Deog ,  CHANG, Cheong-Ho

IPC分类号： A61M5/178

CPC分类号： A61K35/35 ,  A61B50/31 ,  A61B2050/3008 ,  A61B2050/3011 ,  A61M39/10

摘要： Provided is a kit for adipose tissue regeneration and a method of using the same. For this purpose, the present invention provides a kit for adipose tissue regeneration constituted in the form of a single set kit (10), wherein the bottom of a kit box equipped with a locking device is provided with a washing container (22) filled with an aseptic and sterile solution for washing adipose tissues and a washing container insertion groove (13) for containing the same; a first syringe container (20) containing first syringes (30) for washing and separation of adipose tissues, injection of the wash solution and mixing of a Bio-Gel, respectively, and an first syringe container insertion groove (11) for containing the same; a second syringe container (21) containing a plurality of second Bio-Gel syringes (40) filled with biocompatible materials to promote adi-pogenesis induction and a second syringe container insertion groove (12) for containing the same; and connector containers (23) containing connectors (60) for use in injection of the wash solution and mixing of washed adipose tissues and biocompatible materials, and connector container insertion grooves (14) for containing the same, and wherein the top of the kit box is provided with needle containers (24) containing transplantation needles (50) and needle container insertion grooves (15) for containing the same; and a protocol (25) in which standardization of fat transplantation is defined and a protocol insertion groove (16) for containing the same.

摘要翻译： 提供了用于脂肪组织再生的试剂盒及其使用方法。 为此，本发明提供了一种用于单个套件（10）形式的用于脂肪组织再生的套件，其中配备有锁定装置的套件箱的底部设置有填充有洗涤容器（22）的洗涤容器 用于清洗脂肪组织的无菌无菌溶液和用于容纳所述脂肪组织的清洗容器插入槽（13） 第一注射器容器20和第一注射器容器插入槽11，第一注射器容器20包括分别用于清洗和分离脂肪组织的第一注射器30，注射洗涤溶液和混合Bio-Gel，第一注射器容器插入槽11用于容纳它们 ; 第二注射器容器（21），所述第二注射器容器（21）包含多个第二生物凝胶注射器（40）和第二注射器容器插入槽（12），所述第二生物凝胶注射器（40）填充有生物相容性材料以促进刺激诱导， 和包含连接器（60）的连接器容器（23），所述连接器用于注射所述洗涤溶液并且混合经清洗的脂肪组织和生物相容性材料，以及用于容纳所述连接器容器插入凹槽（14），并且其中所述试剂盒盒 设置有包含移植针（50）的针容器（24）和用于容纳移植针（50）的针容器插入槽（15） 和其中定义了脂肪移植的标准化的方案（25）以及用于包含脂肪移植的方案插入槽（16）。

公开(公告)号：EP2049649A1

公开(公告)日：2009-04-22

申请号：EP07708957.1

申请日：2007-02-15

申请人： Sewon Cellontech Co., Ltd.

发明人： CHOI, Jeong-Yong ,  SUH, Dong-Sam ,  KO, Chang-Kwon ,  RYU, Seung-Ju ,  CHANG, Hyang-Soon ,  CHUNG, Jin-Wook ,  CHANG, Cheong-Ho

IPC分类号： C12M1/18

CPC分类号： C12M37/00 ,  B01L1/04 ,  F24F3/1607

摘要： Disclosed is cell manipulation and cultivation equipment for the production of cell therapy products, for preventing contamination of cells and improving the utility of a space. The equipment includes a room for the production and testing of cell therapy products, the room having an inner space enclosed in all sides and an outer entrance/exit door provided at any one side thereof, an L-shaped partition installed in a position of the room for the production and testing of cell therapy products, the partition having an inner entrance/exit door provided at any one side thereof, and a clean bench device placed inside the partition, the clean bench device including first, second, and third clean benches for preventing contamination of cells and increasing the utility of a space to the maximum extent. The cell manipulation and cultivation equipment can provide the advantages of a remarkably improved clean operating room or clean bench, enhanced space utility, agreeable operating environment, and convenience of use via additional convenience facilities, thereby preventing contamination of equipment for the cultivation and production of cell therapy products, and achieving a great improvement in the quality and reliability of cell therapy products, so as to give a good image to consumers.

公开(公告)号：EP2018419A1

公开(公告)日：2009-01-28

申请号：EP06769014.9

申请日：2006-06-23

申请人： Sewon Cellontech Co., Ltd.

发明人： PARK, Hyun-Shin ,  JANG, Jae-Deog ,  LEE, Sae-Bom ,  CHANG, Cheong-Ho

IPC分类号： C12N5/08

CPC分类号： C12N5/0654 ,  A61K35/28

摘要： The present invention relates to a method for separating bone marrow-derived nucleated cells for bone formation. The method comprises: the steps of: washing bone marrow; lysing red blood cells in the bone marrow; neutralizing the bone marrow lysate; purifying nucleated cells from the neutralized bone marrow; and mixing the nucleated cells with a maintenance buffer for bone formation. According to the invention, bone marrow-derived nucleated cells, which can be grafted into a site in need of bone formation or bone defect treatment, can be separated in a rapid and convenient manner. As a result, bone formation in emergency patients or patients, who require repeated surgical operations, can be effectively achieved by separating the nucleated cells for bone formation in surgical locations in a convenient and rapid manner and injecting the separated cells into the patients.