公开(公告)号：EP4378451A1

公开(公告)日：2024-06-05

申请号：EP22848634.6

申请日：2022-07-28

申请人： Shanghai Aurora Biotechnology Co., Ltd.

发明人： GUO, Zhen ,  WANG, Xuan ,  LU, Pengcheng ,  FU, Jun ,  WANG, Tingting ,  YING, Shuhuan

IPC分类号： A61K9/08 ,  A61K31/506 ,  A61P35/00

CPC分类号： A61K47/44 ,  A61K47/32 ,  A61K47/10 ,  A61K47/34 ,  A61K47/26 ,  A61P35/00 ,  A61K31/506 ,  A61K47/38 ,  A61K9/08

摘要： Provided are a pazopanib oral pharmaceutical composition, and a preparation method therefor and the use thereof. Provided is a pazopanib oral pharmaceutical composition, which comprises an active drug, a polymer carrier, an organic solvent and/or water, wherein the active drug is 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide as represented by formula I and a salt thereof. Dispersion of pazopanib in the form of a solution can significantly improve the solubility and dissolution rate of pazopanib, can significantly increase the drug bioavailability, and can also improve the compliance of a patient and solve the problems of dysphagia in elderly patients, etc.