公开(公告)号：EP3498722A1

公开(公告)日：2019-06-19

申请号：EP16913036.6

申请日：2016-08-15

申请人： Shanghai Green Valley Pharmaceutical Co., Ltd.

发明人： XIAO, Zhongping ,  ZHANG, Zhenqing ,  GENG, Meiyu ,  DING, Jian

IPC分类号： C07H1/00 ,  C07H7/033

摘要： The invention relates to a new method of preparing oligomannuronic diacids, important bioactives. The method utilizes oligomannuronic acids as starting materials and the target substances are obtained by acid degradation and active hypobromous acid oxidation steps. The method of preparing oligomannuronic diacids according to the invention employs moderate reaction conditions, has few side reactions, does not need further purification, achieves a yield of more than 90%, or even more than 95%, and is suitable for production with an on-line continuous reactor device, with reaction processes easy to implement automatic control.

公开(公告)号：EP4011378A1

公开(公告)日：2022-06-15

申请号：EP20849500.2

申请日：2020-08-05

申请人： Shanghai Green Valley Pharmaceutical Co., Ltd. ,  Shanghai Institute Materia Medica, Chinese Academy Of Sciences

发明人： GENG, Meiyu ,  SUN, Guangqiang ,  WANG, Xinyi ,  ZHANG, Jing ,  FENG, Teng

IPC分类号： A61K31/702 ,  A61P3/10 ,  A61P19/02

摘要： A use that relates to mannuronic acid oligosaccharides or a composition comprising same in the treatment of Th1-dominance related diseases. The Th1-dominance related diseases may be selected from Multiple Sclerosis, Crohn's disease, Type I Diabetes, Rheumatoid Arthritis, Hashimoto's thyroiditis, vitiligo, Sjögren's Syndrome, Polycystic ovary syndrome, Celiac Disease and Grave's disease, preferably from Multiple Sclerosis, Crohn's disease and Rheumatoid Arthritis.

公开(公告)号：EP3815692A1

公开(公告)日：2021-05-05

申请号：EP19825647.1

申请日：2019-06-28

申请人： Shanghai Green Valley Pharmaceutical Co., Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： GENG, Meiyu ,  ZHANG, Zhenqing ,  JIN, Yingshen ,  XIAO, Zhongping ,  DING, Jian

IPC分类号： A61K31/702 ,  A61P25/28 ,  A61P25/16 ,  A61P29/00 ,  A61P25/04 ,  A61P3/10

摘要： The present invention relates to an alginic oligosaccharic diacid composition comprising a mannuronic diacid of Formula (IV) or a pharmaceutically acceptable salt thereof, wherein n is an integer selected from 1 to 9, m is selected from 0, 1 or 2, m' is selected from 0 or 1, and wherein the total weight of alginic oligosaccharic diacid wherein n=1-5 accounts for more than 60% of the total weight of the composition; the total weight of guluronic acids accounts for less than 50% of the total weight of the composition.

公开(公告)号：EP3815691A1

公开(公告)日：2021-05-05

申请号：EP19825144.9

申请日：2019-06-28

申请人： Shanghai Green Valley Pharmaceutical Co., Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： GENG, Meiyu ,  XIN, Xianliang ,  DU, Xiaoguang ,  ZHANG, Zhenqing ,  DING, Jian

IPC分类号： A61K31/702 ,  A61P25/16

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of Parkinson's disease.

公开(公告)号：EP3815695A1

公开(公告)日：2021-05-05

申请号：EP19826543.1

申请日：2019-06-28

申请人： Shanghai Green Valley Pharmaceutical Co., Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： GENG, Meiyu ,  XIN, Xianliang ,  ZHANG, Zhenqing ,  DING, Jian

IPC分类号： A61K31/702 ,  A61P25/04

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of pain.

公开(公告)号：EP3815694A1

公开(公告)日：2021-05-05

申请号：EP19826046.5

申请日：2019-06-28

申请人： Shanghai Green Valley Pharmaceutical Co., Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： GENG, Meiyu ,  XIN, Xianliang ,  DU, Xiaoguang ,  ZHANG, Zhenqing ,  DING, Jian

IPC分类号： A61K31/702 ,  A61P25/28

摘要： The present invention relates to the application of mannuronic diacid oligosaccharide composition in the treatment of vascular dementia.

公开(公告)号：EP3815690A1

公开(公告)日：2021-05-05

申请号：EP19824488.1

申请日：2019-06-28

申请人： Shanghai Green Valley Pharmaceutical Co., Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： GENG, Meiyu ,  XIN, Xianliang ,  ZHANG, Zhenqing ,  DING, Jian

IPC分类号： A61K31/702 ,  A61P3/10

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of diabetes.

公开(公告)号：EP4011395A1

公开(公告)日：2022-06-15

申请号：EP20850878.8

申请日：2020-08-05

申请人： Shanghai Green Valley Pharmaceutical Co., Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： GENG, Meiyu ,  SUN, Guangqiang ,  WANG, Xinyi ,  ZHANG, Jing ,  FENG, Teng

IPC分类号： A61K45/00 ,  A61P25/28

摘要： The present invention relates to identification of a carbohydrate drug-sensitive patient in patients having Alzheimer's disease. The present invention provides a method for identifying a carbohydrate drug-sensitive patient in patients having Alzheimer's disease.

公开(公告)号：EP4011394A1

公开(公告)日：2022-06-15

申请号：EP20850618.8

申请日：2020-08-05

申请人： Shanghai Green Valley Pharmaceutical Co., Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： GENG, Meiyu ,  SUN, Guangqiang ,  WANG, Xinyi ,  ZHANG, Jing ,  FENG, Teng

IPC分类号： A61K45/00 ,  A61K31/702 ,  G01N33/483 ,  A61P3/10

摘要： Provided is the use of a reagent for inhibiting the uptake of amino acids by naive T cells in the preparation of a drug for treating Alzheimer's disease in a subject.

公开(公告)号：EP4011392A1

公开(公告)日：2022-06-15

申请号：EP20849639.8

申请日：2020-08-05

申请人： Shanghai Green Valley Pharmaceutical Co., Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： GENG, Meiyu ,  SUN, Guangqiang ,  WANG, Xinyi ,  ZHANG, Jing ,  FENG, Teng

IPC分类号： A61K45/00 ,  A61P25/28

摘要： The present invention relates to the treatment of Alzheimer's disease. Provided is the use of an reagent for regulating the relative abundance of intestinal microorganisms in the preparation of a medicament for treating Alzheimer's disease in a subjet.