公开(公告)号：EP1995249A1

公开(公告)日：2008-11-26

申请号：EP07702109.5

申请日：2007-01-17

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： LU, Wei ,  DING, Jian ,  GAO, Heyong ,  LIN, Liping ,  CHEN, Yi

IPC分类号： C07D491/22 ,  A61K31/475 ,  A61P35/00 ,  C07D221/00 ,  C07D209/00 ,  C07D311/00

CPC分类号： C07D491/22

摘要： New camptothecin derivatives with the following structure of the formula (I), their use and the pharmaceutical compositions containing the same. The compounds of the present invention have good anti-tumor activities and good solubility in water, and can be used in development of medicines.

摘要翻译： 具有以下式（I）结构的新的喜树碱衍生物，它们的用途和含有它们的药物组合物。 本发明化合物具有良好的抗肿瘤活性和在水中的良好溶解性，可用于药物开发。

公开(公告)号：EP1995249B1

公开(公告)日：2010-11-10

申请号：EP07702109.5

申请日：2007-01-17

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： LU, Wei ,  DING, Jian ,  GAO, Heyong ,  LIN, Liping ,  CHEN, Yi

IPC分类号： C07D491/22 ,  A61K31/4745 ,  A61P35/00

CPC分类号： C07D491/22

摘要： New camptothecin derivatives with the following structure of the formula (I), their use and the pharmaceutical compositions containing the same. The compounds of the present invention have good anti-tumor activities and good solubility in water, and can be used in development of medicines.