专利检索 ap:("Shanghai Institute of Materia Medica, Chinese Academy of Sciences" OR "Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.") AND inv:"CHEN, Lin" 第 1 页

1.

发明授权
PROCESS OF SYNTHESIZING SUBSTITUTED PYRIDINE AND PYRIMIDINE COMPOUND 有权

公开(公告)号：EP3275882B1

公开(公告)日：2020-09-23

申请号：EP16767773.1

申请日：2016-03-24

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

发明人： SHEN, Jingkang , MENG, Tao , YU, Ting , MA, Lanping , WANG, Xin , CHEN, Lin

IPC分类号： C07D471/04 , C07D519/00

2.

发明公开
PROCESS OF SYNTHESIZING SUBSTITUTED PYRIDINE AND PYRIMIDINE COMPOUND 审中-公开
标题翻译：合成取代的吡啶和嘧啶化合物的方法

公开(公告)号：EP3275882A1

公开(公告)日：2018-01-31

申请号：EP16767773.1

申请日：2016-03-24

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

发明人： SHEN, Jingkang , MENG, Tao , YU, Ting , MA, Lanping , WANG, Xin , CHEN, Lin

IPC分类号： C07D471/04 , C07D519/00

CPC分类号： C07D471/04 , C07D519/00

摘要： Provided is a process of synthesizing a substituted pyridine and pyrimidine compound. Particularly, provided is a method for preparing a compound of formula III via a compound of formula II', wherein the definition of each of groups is as described as the description. Compound with other methods, the method in the present invention has features of high yield and a result product being easier to separate.

摘要翻译： 提供了合成取代的吡啶和嘧啶化合物的方法。特别地，提供了通过式II'化合物制备式III化合物的方法，其中每个基团的定义如说明书所述。与其他方法化合物相比，本发明方法具有收率高，结果产物易于分离的特点。

3.

发明公开
AXL-TARGETING ANTIBODY, ANTIBODY-DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF 审中-公开

公开(公告)号：EP3808773A2

公开(公告)日：2021-04-21

申请号：EP19803867.1

申请日：2019-05-10

申请人： Fudan University , Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： YU, Ke , SHEN, Jingkang , MENG, Tao , PEI, Jinpeng , MA, Lanping , WANG, Xin , JIN, Rui , DU, Zhiyan , CHEN, Lin , YU, Ting , ZHANG, Yongliang

IPC分类号： C07K16/28 , C07K19/00 , A61K39/395 , A61K47/68 , A61P35/00

摘要： Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified humanAXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.